Science. 1978 Mar 24;199(4335):1345-6.

Nonhistone proteins HMG1 and HMG2 change the DNA helical structure.

Abstract

Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.

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Nonhistone proteins HMG1 and HMG2 unwind DNA double helix. [Nucleic Acids Res. 1979]
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Javaherian K, Sadeghi M, Liu LF. Nucleic Acids Res. 1979 Aug 10; 6(11):3569-80.
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