N Engl J Med. 1978 Mar 9;298(10):531-4.

Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.

Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB.

Abstract

A substance producing cytotoxicity in tissue culture was detected in stool specimens from all of four patients with pseudomembranous colitis due to antibiotics and in one of 54 with antibiotic-associated diarrhea. These stools also caused enterocolitis when injected intracecally into hamsters. On each occasion, cytotoxicity in tissue culture and enterocolitis in hamsters were neutralized by pretreatment with gas-gangrene antitoxin. The toxicity in both tissue cultures and hamsters could be reproduced with broth cultures of clostridia strains isolated from four of the five stools. These results suggest that toxin-producing clostridia are responsible for antibiotic-associated pseudomembranous colitis.

PMID:: 625309; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Medical

Antibiotics - MedlinePlus Health Information

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Antibiotic-induced lethal enterocolitis in hamsters: studies with eleven agents and evidence to support the pathogenic role of toxin-producing Clostridia. [Am J Vet Res. 1978]
Antibiotic-induced lethal enterocolitis in hamsters: studies with eleven agents and evidence to support the pathogenic role of toxin-producing Clostridia.
Bartlett JG, Chang TW, Moon N, Onderdonk AB. Am J Vet Res. 1978 Sep; 39(9):1525-30.
Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis. [Gastroenterology. 1978]
Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis.
Bartlett JG, Moon N, Chang TW, Taylor N, Onderdonk AB. Gastroenterology. 1978 Nov; 75(5):778-82.
Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. [J Infect Dis. 1977]
Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.
Bartlett JG, Onderdonk AB, Cisneros RL, Kasper DL. J Infect Dis. 1977 Nov; 136(5):701-5.
Review Antibiotic-associated pseudomembranous colitis. [Rev Infect Dis. 1979]
Review Antibiotic-associated pseudomembranous colitis.
Bartlett JG. Rev Infect Dis. 1979 May-Jun; 1(3):530-9.
Review Antibiotic-associated colitis. [Clin Gastroenterol. 1979]
Review Antibiotic-associated colitis.
Bartlett JG. Clin Gastroenterol. 1979 Sep; 8(3):783-801.

See reviews... See all...

Cited by over 100 PubMed Central articles

Clostridium difficile Infection and Inflammatory Bowel Disease: A Review. [Gastroenterol Res Pract. 2011]
Clostridium difficile Infection and Inflammatory Bowel Disease: A Review.
Sinh P, Barrett TA, Yun L. Gastroenterol Res Pract. 2011; 2011:136064. Epub 2011 Sep 12.
Binary toxin and death after Clostridium difficile infection. [Emerg Infect Dis. 2011]
Binary toxin and death after Clostridium difficile infection.
Bacci S, Mølbak K, Kjeldsen MK, Olsen KE. Emerg Infect Dis. 2011 Jun; 17(6):976-82.
The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A. [PLoS One. 2011]
The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A.
Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R. PLoS One. 2011 Mar 18; 6(3):e17623. Epub 2011 Mar 18.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia...
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.
N Engl J Med. 1978 Mar 9 ;298(10):531-4.

PubMed
Cellular response to respiratory viruses with particular reference to children w...
Cellular response to respiratory viruses with particular reference to children with disorders of cell-mediated immunity.
J Pediatr. 1980 Feb ;96(2):179-86.

PubMed
Collateral ventilation in man.
Collateral ventilation in man.
N Engl J Med. 1978 Jan 5 ;298(1):10-5.

PubMed
Endotoxemia in a series of 104 patients with chronic liver diseases: prevalence ...
Endotoxemia in a series of 104 patients with chronic liver diseases: prevalence and significance.
Digestion. 1982 ;23(4):239-44.

PubMed
A prospective study of nontraumatic coma: methods and results in 310 patients.
A prospective study of nontraumatic coma: methods and results in 310 patients.
Ann Neurol. 1977 Sep ;2(3):211-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information