Connect Tissue Res. 1983;11(2-3):95-102.

An in situ study of the influence of a sclerosing solution in rabbit medial collateral ligaments and its junction strength.

Liu YK, Tipton CM, Matthes RD, Bedford TG, Maynard JA, Walmer HC.

Abstract

A double-blind study was conducted to assess the influence of a sclerosing solution on rabbit medial collateral ligaments (MCL) in situ. It was shown that repeated injections of 5% sodium morrhuate into the MCL and its bony attachments significantly increased its bone-ligament-bone junction strength, ligament mass and thickness when compared to saline-injected controls. Morphometric analysis of electron micrographs showed a highly significant corresponding increase of the collagen fibril diameters in the experimental ligament compared against the control MCL. These composite findings suggested that the sclerosing solution had a significant influence on dense connective tissue at the insertion sites. The mechanisms for these changes are uncertain and are the basis for future investigations.

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