Eur J Pharmacol. 1978 Oct 1;51(3):291-4.

"Behavioural despair" in rats and mice: strain differences and the effects of imipramine.

Abstract

Rats and mice when forced to swim in a restricted space will rapidly cease attempts to escape and become immobile. Previous experiments have shown that immobility was selectively reduced by antidepressant agents. The present experiments show that important differences exist between strains in both the amount of immobility observed and the effects of imipramine. Strain differences should therefore be taken into account in attempts to replicate results from one laboratory to another.

PMID:: 568552; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Imipramine

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Non-specificity of "behavioral despair" as an animal model of depression. [Eur J Pharmacol. 1979]
Non-specificity of "behavioral despair" as an animal model of depression.
Schechter MD, Chance WT. Eur J Pharmacol. 1979 Dec 7; 60(2-3):139-42.
Individual differences in response to imipramine in the mouse tail suspension test. [Psychopharmacology (Berl). 1997]
Individual differences in response to imipramine in the mouse tail suspension test.
Vaugeois JM, Passera G, Zuccaro F, Costentin J. Psychopharmacology (Berl). 1997 Dec; 134(4):387-91.
The immobility response in the forced swim test: paradoxical effect of imipramine. [Eur J Pharmacol. 1994]
The immobility response in the forced swim test: paradoxical effect of imipramine.
Abel EL, Hannigan JH. Eur J Pharmacol. 1994 Jun 13; 258(3):261-4.
Review Ethopharmacology of imipramine in the forced-swimming test: gender differences. [Neurosci Biobehav Rev. 1998]
Review Ethopharmacology of imipramine in the forced-swimming test: gender differences.
Barros HM, Ferigolo M. Neurosci Biobehav Rev. 1998; 23(2):279-86.
Review The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. [Neurosci Biobehav Rev. 2005]
Review The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice.
Cryan JF, Mombereau C, Vassout A. Neurosci Biobehav Rev. 2005; 29(4-5):571-625.

See reviews... See all...

Cited by 20 PubMed Central articles

Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice. [Evid Based Complement Alternat...]
Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice.
Hsu LC, Ko YJ, Cheng HY, Chang CW, Lin YC, Cheng YH, Hsieh MT, Peng WH. Evid Based Complement Alternat Med. 2012; 2012:497302. Epub 2012 Apr 9.
Effects of stimulation and blockade of d(2) receptor on depression-like behavior in ovariectomized female rats. [ISRN Pharmacol. 2012]
Effects of stimulation and blockade of d(2) receptor on depression-like behavior in ovariectomized female rats.
Fedotova J. ISRN Pharmacol. 2012; 2012:305645. Epub 2012 Mar 1.
Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats. [PLoS One. 2011]
Hippocampal neurogenesis and dendritic plasticity support running-improved spatial learning and depression-like behaviour in stressed rats.
Yau SY, Lau BW, Tong JB, Wong R, Ching YP, Qiu G, Tang SW, Lee TM, So KF. PLoS One. 2011; 6(9):e24263. Epub 2011 Sep 15.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

"Behavioural despair" in rats and mice: strain differences and the effects of im...
"Behavioural despair" in rats and mice: strain differences and the effects of imipramine.
Eur J Pharmacol. 1978 Oct 1 ;51(3):291-4.

PubMed
Stereochemical criteria for polypeptides and proteins. V. Conformation of a syst...
Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide units.
Biopolymers. 1968 Oct ;6(10):1425-36.

PubMed
Recovery as a function of the degree of amnesia due to protein synthesis inhibit...
Recovery as a function of the degree of amnesia due to protein synthesis inhibition.
Pharmacol Biochem Behav. 1978 Jun ;8(6):701-10.

PubMed
Rates, interview, and pathology study of cancer of the urinary bladder in New Or...
Rates, interview, and pathology study of cancer of the urinary bladder in New Orleans, Louisiana.
J Natl Cancer Inst. 1968 Sep ;41(3):683-709.

PubMed
Biotin-binding protein from egg yolk. A protein distinct from egg white avidin.
Biotin-binding protein from egg yolk. A protein distinct from egg white avidin.
J Biol Chem. 1978 Oct 10 ;253(19):6979-82.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

"Behavioural despair" in rats and mice: strain differences and the effects of imipramine.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 20 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information