Anesth Analg. 1978 Sep-Oct;57(5):577-9.

Tracheal pathology following short-term intubation with low- and high-pressure endotracheal tube cuffs.

Loeser EA, Hodges M, Gliedman J, Stanley TH, Johansen RK, Yonetani D.

Abstract

Histologic sections of dog tracheas were taken from 20 dogs anesthetized and intubated for 5 to 7 hours with high-pressure, low-volume Shiley or low-pressure, high-volume Lanz endo-tracheal tubes. Microscopic examination and measurement showed that while the high-pressure, low-volume cuff produced deeper average mucosal erosion, the large-volume, low-pressure cuff resulted in significantly greater lengths of tracheal mucosa-cuff erosion. Maximal depth of penetration throught the basement membrane was similar in both groups. Grooves in the mucosa were seen in 50% of the high-volume-cuff trachea sections but none of the low-volume-cuff tracheal sections. These findings demonstrate that low-pressure, high-volume endotracheal tube cuffs produce different but significant tracheal damage after short-term intubation when compared to high-pressure, low-volume cuffs.

PMID:: 568428; [PubMed - indexed for MEDLINE]

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