Abstract
DNA transcripts of infectious RNA viruses were found to be integrated in the DNA of chronically-infected tissue cultures. DNA sequences homologous to RNA of measles virus were found in tissues affected with systemic lupus erythemotosus. These data open up a new class of virus-cell interaction that may be a result of cooperation between infectious and oncogenic viruses.
MeSH terms
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Animals
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Chick Embryo
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Culture Techniques
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DNA, Viral / metabolism*
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Dactinomycin / pharmacology
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Humans
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Lupus Erythematosus, Systemic / immunology
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Lupus Erythematosus, Systemic / microbiology*
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Measles virus / immunology
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Measles virus / metabolism*
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Oncogenic Viruses / metabolism
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RNA Viruses / metabolism*
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RNA-Directed DNA Polymerase / metabolism
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Transcription, Genetic / drug effects
Substances
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DNA, Viral
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Dactinomycin
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RNA-Directed DNA Polymerase