Cancer. 1979 Nov;44(5):1913-8.

The natural history of breast cancer patients with brain metastases.

DiStefano A, Yong Yap Y, Hortobagyi GN, Blumenschein GR.

Abstract

One hundred one breast cancer patients with brain metastases (BM) were reviewed. The median survival from BM was 4.0 months. Seventy percent were receiving chemotherapy at the diagnosis of BM and 43% were showing a clinical response. Prolonged survival was seen in patients who underwent surgical resection, those with the brain as site of first metastasis, and those with a long free interval who survived the initial 5 months after BM. Long-term survivors (greater than 18 months from BM) demonstrated indolent disease by all parameters measured.

PMID:: 498057; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Antineoplastic Agents

LinkOut - more resources

Other Literature Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Brain metastases in breast cancer: prognostic factors and management. [Breast Cancer Res Treat. 2008]
Brain metastases in breast cancer: prognostic factors and management.
Lee SS, Ahn JH, Kim MK, Sym SJ, Gong G, Ahn SD, Kim SB, Kim WK. Breast Cancer Res Treat. 2008 Oct; 111(3):523-30. Epub 2007 Nov 8.
Treatment and prognosis of brain metastases from breast cancer. [J Neurooncol. 2008]
Treatment and prognosis of brain metastases from breast cancer.
Ogawa K, Yoshii Y, Nishimaki T, Tamaki N, Miyaguni T, Tsuchida Y, Kamada Y, Toita T, Kakinohana Y, Tamaki W, et al. J Neurooncol. 2008 Jan; 86(2):231-8. Epub 2007 Sep 12.
Brain metastases in breast cancer: clinical and pathologic characteristics associated with improvements in survival. [J Neurooncol. 2008]
Brain metastases in breast cancer: clinical and pathologic characteristics associated with improvements in survival.
Melisko ME, Moore DH, Sneed PK, De Franco J, Rugo HS. J Neurooncol. 2008 Jul; 88(3):359-65. Epub 2008 Apr 9.
Review Two cases with long-term disease-free survival after resection and radiotherapy for solitary brain metastasis from breast cancer with extensive nodal metastases. [Breast Cancer. 2005]
Review Two cases with long-term disease-free survival after resection and radiotherapy for solitary brain metastasis from breast cancer with extensive nodal metastases.
Saisho S, Takashima S, Ohsumi S, Saeki H, Aogi K, Saeki T, Mandai K, Iwata S, Takeda T. Breast Cancer. 2005; 12(3):221-5.
Review A summary of two clinical studies on tumor cell dissemination in primary and metastatic breast cancer: methods, prognostic significance and implication for alternative treatment protocols (Review). [Int J Oncol. 2002]
Review A summary of two clinical studies on tumor cell dissemination in primary and metastatic breast cancer: methods, prognostic significance and implication for alternative treatment protocols (Review).
Kasimir-Bauer S, Oberhoff C, Schindler AE, Seeber S. Int J Oncol. 2002 May; 20(5):1027-34.

See reviews... See all...

Cited by 17 PubMed Central articles

Therapeutic effect of gamma knife radiosurgery for multiple brain metastases. [J Korean Neurosurg Soc. 2011]
Therapeutic effect of gamma knife radiosurgery for multiple brain metastases.
Lee CK, Lee SR, Cho JM, Yang KA, Kim SH. J Korean Neurosurg Soc. 2011 Sep; 50(3):179-84. Epub 2011 Sep 30.
Long survival in a patient with brain metastases from breast cancer. [Clin Med Oncol. 2008]
Long survival in a patient with brain metastases from breast cancer.
G S, G P, M CR, C M, F N. Clin Med Oncol. 2008; 2:103-8. Epub 2008 Feb 9.
Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: a meta-analysis of published randomized controlled trials. [PLoS One. 2011]
Trastuzumab in the adjuvant treatment of HER2-positive early breast cancer patients: a meta-analysis of published randomized controlled trials.
Yin W, Jiang Y, Shen Z, Shao Z, Lu J. PLoS One. 2011; 6(6):e21030. Epub 2011 Jun 9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The natural history of breast cancer patients with brain metastases.
The natural history of breast cancer patients with brain metastases.
Cancer. 1979 Nov ;44(5):1913-8.

PubMed
Characterization of the deoxyribonucleic acid of various strains of halophilic b...
Characterization of the deoxyribonucleic acid of various strains of halophilic bacteria.
J Bacteriol. 1969 Jul ;99(1):248-54.

PubMed
Opposed adducting saccades in convergence-retraction nystagmus: a patient with s...
Opposed adducting saccades in convergence-retraction nystagmus: a patient with sylvian aqueduct syndrome.
Brain. 1979 Sep ;102(3):497-508.

PubMed
The eclectroretinogram: its components and their origins.
The eclectroretinogram: its components and their origins.
Vision Res. 1968 Jun ;8(6):633-77.

PubMed
A multiple testing procedure for clinical trials.
A multiple testing procedure for clinical trials.
Biometrics. 1979 Sep ;35(3):549-56.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: