Biometrics. 1979 Sep;35(3):549-56.

A multiple testing procedure for clinical trials.

Abstract

A multiple testing procedure is proposed for comparing two treatments when response to treatment is both dichotomous (i.e., success or failure) and immediate. The proposed test statistic for each test is the usual (Pearson) chi-square statistic based on all data collected to that point. The maximum number (N) of tests and the number (m1 + m2) of observations collected between successive tests is fixed in advance. The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations. The power is also found to be virtually the same. However, by affording the opportunity to terminate early when one treatment performs markedly better than the other, the multiple testing procedure may eliminate the ethical dilemmas that often accompany clinical trials.

PMID:: 497341; [PubMed - indexed for MEDLINE]

MeSH Terms

LinkOut - more resources

Other Literature Sources

Education

New England Research Institutes Inc.

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

One-sample multiple testing procedure for phase II clinical trials. [Biometrics. 1982]
One-sample multiple testing procedure for phase II clinical trials.
Fleming TR. Biometrics. 1982 Mar; 38(1):143-51.
Optimal designs for clinical trials with dichotomous responses. [Stat Med. 1985]
Optimal designs for clinical trials with dichotomous responses.
Berry DA, Pearson LM. Stat Med. 1985 Oct-Dec; 4(4):497-508.
Further results on a multiple-testing procedure for clinical trials. [Biometrics. 1983]
Further results on a multiple-testing procedure for clinical trials.
Seigel D, Milton RC. Biometrics. 1983 Dec; 39(4):921-8.
Review Guided tissue regeneration for periodontal infra-bony defects. [Cochrane Database Syst Rev. 2001]
Review Guided tissue regeneration for periodontal infra-bony defects.
Needleman IG, Giedrys-Leeper E, Tucker RJ, Worthington HV. Cochrane Database Syst Rev. 2001; (2):CD001724.
Review A comparison of goodness-of-fit tests for the logistic regression model. [Stat Med. 1997]
Review A comparison of goodness-of-fit tests for the logistic regression model.
Hosmer DW, Hosmer T, Le Cessie S, Lemeshow S. Stat Med. 1997 May 15; 16(9):965-80.

See reviews... See all...

Cited by over 100 PubMed Central articles

Efficacy of early neonatal vitamin A supplementation in reducing mortality during infancy in Ghana, India and Tanzania: study protocol for a randomized controlled trial. [Trials. 2012]
Efficacy of early neonatal vitamin A supplementation in reducing mortality during infancy in Ghana, India and Tanzania: study protocol for a randomized controlled trial.
NEOVITA Study Author Group, Bahl R, Bhandari N, Dube B, Edmond K, Fawzi W, Fontaine O, Kaur J, Kirkwood BR, Martines J, et al. Trials. 2012 Feb 23; 13:22. Epub 2012 Feb 23.
Benefits, challenges and obstacles of adaptive clinical trial designs. [Orphanet J Rare Dis. 2011]
Benefits, challenges and obstacles of adaptive clinical trial designs.
Chow SC, Corey R. Orphanet J Rare Dis. 2011 Nov 30; 6:79. Epub 2011 Nov 30.
Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. [N Engl J Med. 2011]
Timing of antiretroviral therapy for HIV-1 infection and tuberculosis.
Havlir DV, Kendall MA, Ive P, Kumwenda J, Swindells S, Qasba SS, Luetkemeyer AF, Hogg E, Rooney JF, Wu X, et al. N Engl J Med. 2011 Oct 20; 365(16):1482-91.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A multiple testing procedure for clinical trials.
A multiple testing procedure for clinical trials.
Biometrics. 1979 Sep ;35(3):549-56.

PubMed
The blood groups of the Brahmins and Rajputs of Garhwal.
The blood groups of the Brahmins and Rajputs of Garhwal.
Hum Biol. 1968 Sep ;40(3):386-95.

PubMed
Effects of rise time on simultaneously recorded auditory-evoked potentials from ...
Effects of rise time on simultaneously recorded auditory-evoked potentials from the early, middle and late ranges.
Audiology. 1979 ;18(5):395-402.

PubMed
Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelle...
Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.
Immunology. 1968 Feb ;14(2):181-96.

PubMed
A biological role for the major histocompatibility antigens.
A biological role for the major histocompatibility antigens.
Lancet. 1975 Jun 28 ;1(7922):1406-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A multiple testing procedure for clinical trials.

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Other Literature Sources

Education

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information