Am J Clin Nutr. 1979 Nov;32(11):2233-6.

Penicillin pharmacokinetics in kwashiorkor.

Buchanan N, Robinson R, Koornhof HJ, Eyberg C.

Abstract

Intravenous penicillin kinetics have been studied in eight children with kwashiorkor on admission to hospital and when rehabilitated. A 75% increase in penicillin clearance was observed with recovery, associated with a fall in half-life; this was probably due to an improvement of both renal plasma flow and tubular function. The present observations and those of other authors working in this area are discussed and an approach to drug dosage of renally excreted drugs in kwashiorkor has been proposed.

PMID:: 495540; [PubMed - indexed for MEDLINE]

Free full text

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Malnutrition - MedlinePlus Health Information

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Gentamicin pharmacokinetics in kwashiorkor. [Br J Clin Pharmacol. 1979]
Gentamicin pharmacokinetics in kwashiorkor.
Buchanan N, Davis MD, Eyberg C. Br J Clin Pharmacol. 1979 Nov; 8(5):451-3.
Antipyrine pharmacokinetics and D-glucaric excretion in kwashiorkor. [Am J Clin Nutr. 1979]
Antipyrine pharmacokinetics and D-glucaric excretion in kwashiorkor.
Buchanan N, Eyberg C, Davis MD. Am J Clin Nutr. 1979 Dec; 32(12):2439-42.
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor. [Eur J Clin Pharmacol. 2000]
The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.
Akinyinka OO, Sowunmi A, Honeywell R, Renwick AG. Eur J Clin Pharmacol. 2000 May; 56(2):153-8.
Review Pharmacokinetics in the elderly. [Clin Pharmacokinet. 1976]
Review Pharmacokinetics in the elderly.
Crooks J, O'Malley K, Stevenson IH. Clin Pharmacokinet. 1976; 1(4):280-96.
Review [Clinical pharmacokinetics of azlocillin]. [Presse Med. 1984]
Review [Clinical pharmacokinetics of azlocillin].
Singlas E, Haegel C. Presse Med. 1984 Mar 29; 13(13):788-96.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Antibiotics in severely malnourished children: systematic review of efficacy, safety and pharmacokinetics. [Bull World Health Organ. 2011]
Review Antibiotics in severely malnourished children: systematic review of efficacy, safety and pharmacokinetics.
Lazzerini M, Tickell D. Bull World Health Organ. 2011 Aug 1; 89(8):594-607. Epub 2011 May 20.
Pathophysiological changes that affect drug disposition in protein-energy malnourished children. [Nutr Metab (Lond). 2009]
Pathophysiological changes that affect drug disposition in protein-energy malnourished children.
Oshikoya KA, Senbanjo IO. Nutr Metab (Lond). 2009 Dec 1; 6:50. Epub 2009 Dec 1.
Cefoxitin: intravenous pharmacokinetics and intramuscular bioavailability in kwashiorkor. [Br J Clin Pharmacol. 1980]
Cefoxitin: intravenous pharmacokinetics and intramuscular bioavailability in kwashiorkor.
Buchanan N, Mithal Y, Witcomb M. Br J Clin Pharmacol. 1980 Jun; 9(6):623-7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Penicillin pharmacokinetics in kwashiorkor.
Penicillin pharmacokinetics in kwashiorkor.
Am J Clin Nutr. 1979 Nov ;32(11):2233-6.

PubMed
Stereospecific analysis of triglycerides.
Stereospecific analysis of triglycerides.
Lipids. 1971 Dec ;6(12):942-56.

PubMed
Adaptation to high-fat diet and carbohydrate-induced satiety in the rat.
Adaptation to high-fat diet and carbohydrate-induced satiety in the rat.
Am J Physiol. 1979 Sep ;237(3):R139-46.

PubMed
Muscle carnitine palmityltransferase deficiency and myoglobinuria.
Muscle carnitine palmityltransferase deficiency and myoglobinuria.
Science. 1973 Nov 20 ;182(4115):929-31.

PubMed
Effects of exogenous testosterone on ovarian weight, follicular morphology and i...
Effects of exogenous testosterone on ovarian weight, follicular morphology and intraovarian progesterone concentration in estrogen-primed hypophysectomized immature female rats.
Biol Reprod. 1979 Mar ;20(2):261-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: