JAMA. 1979 Nov 16;242(20):2193-6.

Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study.

Zapol WM, Snider MT, Hill JD, Fallat RJ, Bartlett RH, Edmunds LH, Morris AH, Peirce EC 2nd, Thomas AN, Proctor HJ, Drinker PA, Pratt PC, Bagniewski A, Miller RG Jr.

Abstract

Nine medical centers collaborated in a prospective randomized study to evaluate prolonged extracorporeal membrane oxygenation (ECMO) as a therapy for severe acute respiratory failure (ARF). Ninety adult patients were selected by common criteria of arterial hypoxemia and treated with either conventional mechanical ventilation (48 patients) or mechanical ventilation supplemented with partial venoarterial bypass (42 patients). Four patients in each group survived. The majority of patients suffered acute bacterial or viral pneumonia (57%). All nine patients with pulmonary embolism and six patients with posttraumatic acute respiratory failure died. The majority of patients died of progressive reduction of transpulmonary gas exchange and decreased compliance due to diffuse pulmonary inflammation, necrosis, and fibrosis. We conclude that ECMO can support respiratory gas exchange but did not increase the probability of long-term survival in patients with severe ARF.

PMID:: 490805; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

EBSCO

Other Literature Sources

Medical

ClinicalTrials.gov

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Probability of survival after prolonged extracorporeal membrane oxygenation in pediatric patients with acute respiratory failure. Extracorporeal Life Support Organization. [Crit Care Med. 1995]
Probability of survival after prolonged extracorporeal membrane oxygenation in pediatric patients with acute respiratory failure. Extracorporeal Life Support Organization.
Green TP, Moler FW, Goodman DM. Crit Care Med. 1995 Jun; 23(6):1132-9.
[Venovenous extracorporeal membrane oxygenation (ECMO) with a heparin-lock bypass system. An effective addition in the treatment of acute respiratory failure (ARDS)]. [Anaesthesist. 1996]
[Venovenous extracorporeal membrane oxygenation (ECMO) with a heparin-lock bypass system. An effective addition in the treatment of acute respiratory failure (ARDS)].
Manert W, Haller M, Briegel J, Hummel T, Kilger E, Polasek J, Forst H, Peter K. Anaesthesist. 1996 May; 45(5):437-48.
Primary use of the venovenous approach for extracorporeal membrane oxygenation in pediatric acute respiratory failure. [Pediatr Crit Care Med. 2003]
Primary use of the venovenous approach for extracorporeal membrane oxygenation in pediatric acute respiratory failure.
Pettignano R, Fortenberry JD, Heard ML, Labuz MD, Kesser KC, Tanner AJ, Wagoner SF, Heggen J. Pediatr Crit Care Med. 2003 Jul; 4(3):291-8.
Review Extracorporeal membrane oxygenation for severe acute respiratory failure. [Crit Care. 2000]
Review Extracorporeal membrane oxygenation for severe acute respiratory failure.
Lewandowski K. Crit Care. 2000; 4(3):156-68. Epub 2000 Apr 12.
Review Non-conventional techniques of ventilatory support. [Crit Care Clin. 1990]
Review Non-conventional techniques of ventilatory support.
Villar J, Winston B, Slutsky AS. Crit Care Clin. 1990 Jul; 6(3):579-603.

See reviews... See all...

Cited by 42 PubMed Central articles

Acute respiratory distress syndrome: pathophysiology and therapeutic options. [J Clin Med Res. 2012]
Acute respiratory distress syndrome: pathophysiology and therapeutic options.
Pierrakos C, Karanikolas M, Scolletta S, Karamouzos V, Velissaris D. J Clin Med Res. 2012 Feb; 4(1):7-16. Epub 2012 Jan 17.
Chinese guidelines for diagnosis and treatment of influenza (2011). [J Thorac Dis. 2011]
Chinese guidelines for diagnosis and treatment of influenza (2011).
Zhong NS, Li YM, Yang ZF, Wang C, Liu YN, Li XW, Shu YL, Wang GF, Gao ZC, Deng GH, et al. J Thorac Dis. 2011 Dec; 3(4):274-89.
Acute respiratory distress syndrome: A clinical review. [Pulm Circ. 2011]
Acute respiratory distress syndrome: A clinical review.
Donahoe M. Pulm Circ. 2011 Apr; 1(2):192-211.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Extracorporeal membrane oxygenation in severe acute respiratory failure. A rando...
Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study.
JAMA. 1979 Nov 16 ;242(20):2193-6.

PubMed
The management of bleeding in hemophilia.
The management of bleeding in hemophilia.
Adv Pediatr. 1969 ;16:365-90.

PubMed
Glucose requirements following burn injury. Parameters of optimal glucose infusi...
Glucose requirements following burn injury. Parameters of optimal glucose infusion and possible hepatic and respiratory abnormalities following excessive glucose intake.
Ann Surg. 1979 Sep ;190(3):274-85.

PubMed
Treatment of diabetic coma with continuous low-dose infusion of insulin.
Treatment of diabetic coma with continuous low-dose infusion of insulin.
Br Med J. 1974 Jun 29 ;2(5921):687-90.

PubMed
Attenuated influenza produced by experimental intranasal inoculation.
Attenuated influenza produced by experimental intranasal inoculation.
J Med Virol. 1979 ;3(3):177-88.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: