Proc Natl Acad Sci U S A. 1970 Dec;67(4):1673-80.

Differences between the ribonucleic acids of transforming and nontransforming avian tumor viruses.

Abstract

The 60-70S RNAs of several transforming and nontransforming avian tumor viruses have different electrophoretic mobilities. The RNA of transforming viruses contains two electrophoretically separable subunit classes: a and b. The relative concentrations of these subunits vary with the virus strain. Avian leukosis viruses and nontransforming derivatives of a sarcoma virus lack subunits of class a. It is suggested that the presence of the class a subunit is related to the transforming ability for fibroblasts of the virus.

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