Pathology. 1979 Jan;11(1):89-94.

Lantadene A toxicity in sheep. A model for cholestasis.

Pass MA, Seawright AA, Lamberton JA, Heath TJ.

Abstract

Liver injury occurred after sheep were injected intravenously with the triperpene acid lantadene A, the toxic principle of the tropical plant Lantana camara. A single dose of 1--3 mg/kg of the compound caused mild hepatocellular injury characterized by transient rises in serum enzymes, with or without hyperbilirubinaemia. Higher doses resulted in hepatic necrosis. When low doses of the triterpene were given repeatedly over several days a cholestatic syndrome developed which appeared identical with that caused by consumption of the plant. This is a disease model which may be of value in experimental studies of intrahepatic cholestasis. This study provides evidence that lantadene A is hepatotoxic and does not require metabolism in the alimentray tract for toxicity in sheep.

PMID:: 431982; [PubMed - indexed for MEDLINE]

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The oral toxicity for sheep of triterpene acids isolated from Lantana camara. [Aust Vet J. 1977]
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Cited by 1 PubMed Central article

Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice. [BMC Complement Altern Med. 2005]
Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice.
Sagar L, Sehgal R, Ojha S. BMC Complement Altern Med. 2005 Sep 17; 5:18. Epub 2005 Sep 17.

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