Immunology. 1978 Jan;34(1):77-86.

Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites.

Abstract

Rhesus monkeys vaccinated with merozoites in FCA are protected against challenge with several strains and variants of Plasmodium knowlesi. Vaccination induces sterilizing immunity which is species specific. Merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera provided these contain high levels of inhibitory antibody. However, vaccination using adjuvants other than FCA may induce inhibitory antibody without clinical protection. In addition, vaccinated animals may become susceptible to challenge 4-5 weeks after splenectomy, although inhibitory antibody levels are not reduced. These observations indicate that immunity induced by merozoite vaccination involves: (i) merozoite blocking (inhibitory) antibody, (ii) specific antibody or immune complexes acting synergistically with cytotoxic splenic cells stimulated by FCA.

PMID:: 414993; [PubMed - indexed for MEDLINE]
PMCID:: PMC1457343

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

Antibodies

LinkOut - more resources

Full Text Sources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Mechanisms of malarial immunity. [Trans R Soc Trop Med Hyg. 1977]
Mechanisms of malarial immunity.
Cohen S. Trans R Soc Trop Med Hyg. 1977; 71(4):283-6.
Merozoite vaccination against Plasmodium knowlesi malaria. [Immunology. 1975]
Merozoite vaccination against Plasmodium knowlesi malaria.
Mitchell GH, Butcher GA, Cohen S. Immunology. 1975 Aug; 29(2):397-407.
Long-term studies on rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi. [Infect Immun. 1977]
Long-term studies on rhesus monkeys (Macaca mulatta) immunized against Plasmodium knowlesi.
Cabrera EJ, Barr ML, Silverman PH. Infect Immun. 1977 Feb; 15(2):461-5.
Review Protective antigens of bloodstage Plasmodium knowlesi parasites. [Philos Trans R Soc Lond B Biol...]
Review Protective antigens of bloodstage Plasmodium knowlesi parasites.
Deans JA. Philos Trans R Soc Lond B Biol Sci. 1984 Nov 13; 307(1131):159-69.
Review Immunity to malaria. [Proc R Soc Lond B Biol Sci. 1979]
Review Immunity to malaria.
Cohen S. Proc R Soc Lond B Biol Sci. 1979 Jan 15; 203(1153):323-45.

See reviews... See all...

Cited by 14 PubMed Central articles

Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model. [PLoS One. 2010]
Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.
Guilbride DL, Gawlinski P, Guilbride PD. PLoS One. 2010 May 19; 5(5):e10685. Epub 2010 May 19.
Review Acquired immunity to malaria. [Clin Microbiol Rev. 2009]
Review Acquired immunity to malaria.
Doolan DL, Dobaño C, Baird JK. Clin Microbiol Rev. 2009 Jan; 22(1):13-36, Table of Contents.
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection. [Malar J. 2008]
Suppression of Plasmodium falciparum by serum collected from a case of Plasmodium vivax infection.
Nagao Y, Kimura-Sato M, Chavalitshewinkoon-Petmitr P, Thongrungkiat S, Wilairatana P, Ishida T, Tan-Ariya P, de Souza JB, Krudsood S, Looareesuwan S. Malar J. 2008 Jun 26; 7:113. Epub 2008 Jun 26.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Antibody mediated mechanisms of immunity to malaria induced by vaccination with ...
Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites.
Immunology. 1978 Jan ;34(1):77-86.

PubMed
Assessment of coma and impaired consciousness. A practical scale.
Assessment of coma and impaired consciousness. A practical scale.
Lancet. 1974 Jul 13 ;2(7872):81-4.

PubMed
Erythrocyte receptors for malaria merozoites.
Erythrocyte receptors for malaria merozoites.
Am J Trop Med Hyg. 1977 Nov ;26(6 Pt 2):204-8.

PubMed
Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria and tryp...
Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria and trypanosomiasis.
Lancet. 1974 Mar 16 ;1(7855):435-6.

PubMed
Electrophoresis of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in ...
Electrophoresis of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in erythrocytes from malaria-infected animals.
Ann Trop Med Parasitol. 1977 Jun ;71(2):125-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: