J Antibiot (Tokyo). 1977 Dec;30(12):1093-7.

Possible beta-lactamase activities detectable in infective clinical specimens.

Abstract

Biological beta-lactam antibiotic-inactivating activities were detected in bacteriuria and suppurating pleural fluids. Clinical specimens were sterilized with membrane filters and the amounts of ampicillin and/or cephalothin which were being inactivated by 1 ml of each filtrate were determined. In general, filtrates which originally yielded Klebsiella sp. tended to show activity against ampicillin; whereas those yielding Enterobacter sp. and Pseudomonas aeruginosa showed activity against cephalothin.

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Possible beta-lactamase activities detectable in infective clinical specimens.

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