Cancer Genet Cytogenet. 1985 Oct;18(2):95-104.

Translocation of c-abl to "masked" Ph in chronic myeloid leukemia.

Hagemeijer A, de Klein A, Gödde-Salz E, Turc-Carel C, Smit EM, van Agthoven AJ, Grosveld GC.

Abstract

In two patients with chronic myeloid leukemia (CML), the nature of the chromosomal rearrangement giving rise to "masked" Ph has been studied by in situ hybridization of human c-abl sequences. The c-abl probes hybridized to the 22q11 region of the "masked" Ph, demonstrating that translocation of sequences from 9q34 to the Ph did occur exactly as in standard Ph or in other types of variants previously studied. These results provide additional evidence for the occurrence of a constant molecular rearrangement in Ph-positive CML.

PMID:: 3863697; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

DNA, Recombinant

LinkOut - more resources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Genomic diversity correlates with clinical variation in Ph'-negative chronic myeloid leukaemia. [Nature. 1986]
Genomic diversity correlates with clinical variation in Ph'-negative chronic myeloid leukaemia.
Morris CM, Reeve AE, Fitzgerald PH, Hollings PE, Beard ME, Heaton DC. Nature. 1986 Mar 20-26; 320(6059):281-3.
Translocation of BCR to chromosome 9: a new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia. [Genes Chromosomes Cancer. 1993]
Translocation of BCR to chromosome 9: a new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia.
Hagemeijer A, Buijs A, Smit E, Janssen B, Creemers GJ, Van der Plas D, Grosveld G. Genes Chromosomes Cancer. 1993 Dec; 8(4):237-45.
Chromosomal in situ hybridization and Southern blot analyses using c-abl, c-sis, or bcr probe in chronic myelogenous leukemia cells with variant Philadelphia translocations. [Cancer Genet Cytogenet. 1989]
Chromosomal in situ hybridization and Southern blot analyses using c-abl, c-sis, or bcr probe in chronic myelogenous leukemia cells with variant Philadelphia translocations.
Abe S, Minamihisamatsu M, Ishihara T, Sasaki M. Cancer Genet Cytogenet. 1989 Mar; 38(1):61-74.
Review Expression of c-abl in Philadelphia-positive acute myelogenous leukemia. [Blood. 1987]
Review Expression of c-abl in Philadelphia-positive acute myelogenous leukemia.
Kurzrock R, Shtalrid M, Talpaz M, Kloetzer WS, Gutterman JU. Blood. 1987 Nov; 70(5):1584-8.
Review Oncogene activation by chromosomal rearrangement in chronic myelocytic leukemia. [Mutat Res. 1987]
Review Oncogene activation by chromosomal rearrangement in chronic myelocytic leukemia.
De Klein A. Mutat Res. 1987 Sep; 186(2):161-72.

See reviews... See all...

Cited by 3 PubMed Central articles

Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report. [Mol Cytogenet. 2009]
Novel complex translocation involving 5 different chromosomes in a chronic myeloid leukemia with Philadelphia chromosome: a case report.
Al Achkar W, Wafa A, Mkrtchyan H, Moassass F, Liehr T. Mol Cytogenet. 2009 Nov 9; 2:21. Epub 2009 Nov 9.
FISH mapping of Philadelphia negative BCR/ABL1 positive CML. [Mol Cytogenet. 2008]
FISH mapping of Philadelphia negative BCR/ABL1 positive CML.
Virgili A, Brazma D, Reid AG, Howard-Reeves J, Valgañón M, Chanalaris A, De Melo VA, Marin D, Apperley JF, Grace C, et al. Mol Cytogenet. 2008 Jul 18; 1:14. Epub 2008 Jul 18.
Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis. [J Exp Med. 1986]
Persistence of chronic myelocytic leukemia despite deletion of rearranged bcr/c-abl sequences in blast crisis.
Bartram CR, Janssen JW, Becher R, de Klein A, Grosveld G. J Exp Med. 1986 Nov 1; 164(5):1389-96.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cancer Chromosomes
Cancer chromosome records that cite the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Translocation of c-abl to "masked" Ph in chronic myeloid leukemia.
Translocation of c-abl to "masked" Ph in chronic myeloid leukemia.
Cancer Genet Cytogenet. 1985 Oct ;18(2):95-104.

PubMed
Genomic diversity correlates with clinical variation in Ph'-negative chronic mye...
Genomic diversity correlates with clinical variation in Ph'-negative chronic myeloid leukaemia.
Nature. 1986 Mar 20-26 ;320(6059):281-3.

PubMed
Related Citations for PubMed (Select 20678245) (109)
PubMed
Related Citations for PubMed (Select 20678246) (108)
PubMed
A large-scale survey of the novel 15q24 microdeletion syndrome in autism spectru...
A large-scale survey of the novel 15q24 microdeletion syndrome in autism spectrum disorders identifies an atypical deletion that narrows the critical region.
Mol Autism. 2010 Mar 19 ;1(1):5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Translocation of c-abl to "masked" Ph in chronic myeloid leukemia.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Libraries

Supplemental Content

Related citations

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information