Arthritis Rheum. 1986 Nov;29(11):1316-21.

Assessment of the potential pathogenicity of type II collagen autoantibodies in patients with rheumatoid arthritis. Evidence of restricted IgG3 subclass expression and activation of complement C5 to C5a.

Watson WC, Cremer MA, Wooley PH, Townes AS.

Abstract

IgG subclass analysis by enzyme-linked immunosorbent assay of the autoantibody to native type II collagen, detected in 9 patients with classic or definite rheumatoid arthritis, demonstrated a predominance of IgG3 autoantibody. Gm allotyping revealed no obvious association with a particular phenotype. In comparative studies, IgG antibodies to the capsular polysaccharides of pneumococci and tetanus toxoid protein in these same patients consisted predominantly of IgG2 and IgG4. Purified type II collagen autoantibody from 3 of these patients activated complement C5 to C5a when bound to human cartilage in vitro, as measured by radioimmunoassay. These results represent direct evidence of a potential pathogenic role for this autoantibody in rheumatoid arthritis.

PMID:: 3778540; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci. [J Exp Med. 1985]
Genetic susceptibility to murine collagen II autoimmune arthritis. Proposed relationship to the IgG2 autoantibody subclass response, complement C5, major histocompatibility complex (MHC) and non-MHC loci.
Watson WC, Townes AS. J Exp Med. 1985 Dec 1; 162(6):1878-91.
IgG subclasses of antibodies to type II collagen in rheumatoid arthritis differ from those in systemic lupus erythematosus and other connective tissue diseases. [J Rheumatol. 1997]
IgG subclasses of antibodies to type II collagen in rheumatoid arthritis differ from those in systemic lupus erythematosus and other connective tissue diseases.
Cook AD, Mackay IR, Cicuttini FM, Rowley MJ. J Rheumatol. 1997 Nov; 24(11):2090-6.
IgG subclass distribution of antinative type II collagen and antidenatured type II collagen antibodies in patients with rheumatoid arthritis. [J Rheumatol. 1988]
IgG subclass distribution of antinative type II collagen and antidenatured type II collagen antibodies in patients with rheumatoid arthritis.
Collins I, Morgan K, Clague RB, Brenchley PE, Holt PJ. J Rheumatol. 1988; 15(5):770-4.
Review IgG3 reactive rheumatoid factor in rheumatoid arthritis: etiologic and pathogenic considerations. [Autoimmunity. 1994]
Review IgG3 reactive rheumatoid factor in rheumatoid arthritis: etiologic and pathogenic considerations.
Wong A, Kenny TP, Ermel R, Robbins DL. Autoimmunity. 1994; 19(3):199-210.
Review Granulocyte-specific antinuclear antibodies. Possible significance for the pathogenesis, clinical features and diagnosis of rheumatoid arthritis. [Allergy. 1980]
Review Granulocyte-specific antinuclear antibodies. Possible significance for the pathogenesis, clinical features and diagnosis of rheumatoid arthritis.
Wiik A. Allergy. 1980 Jun; 35(4):263-89.

See reviews... See all...

Cited by 7 PubMed Central articles

Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice. [Arthritis Res Ther. 2006]
Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice.
Sakurai Y, Brand DD, Tang B, Rosloniec EF, Stuart JM, Kang AH, Myers LK. Arthritis Res Ther. 2006; 8(5):R150.
An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. [J Exp Med. 1997]
An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen.
Rosloniec EF, Brand DD, Myers LK, Whittington KB, Gumanovskaya M, Zaller DM, Woods A, Altmann DM, Stuart JM, Kang AH. J Exp Med. 1997 Mar 17; 185(6):1113-22.
The collagen-like component of the complement system, C1q, is recognized by 7 S autoantibodies and is functionally impaired in synovial fluids of patients with rheumatoid arthritis. [Immunology. 1996]
The collagen-like component of the complement system, C1q, is recognized by 7 S autoantibodies and is functionally impaired in synovial fluids of patients with rheumatoid arthritis.
Trinder PK, Maeurer MJ, Brackertz D, Loos M. Immunology. 1996 Mar; 87(3):355-61.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Assessment of the potential pathogenicity of type II collagen autoantibodies in ...
Assessment of the potential pathogenicity of type II collagen autoantibodies in patients with rheumatoid arthritis. Evidence of restricted IgG3 subclass expression and activation of complement C5 to C5a.
Arthritis Rheum. 1986 Nov ;29(11):1316-21.

PubMed
Long-term second-line treatment: a prospective drug survival study.
Long-term second-line treatment: a prospective drug survival study.
Br J Rheumatol. 1992 Apr ;31(4):253-8.

PubMed
A randomized trial comparing aerobic exercise and resistance exercise with a hea...
A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST).
JAMA. 1997 Jan 1 ;277(1):25-31.

PubMed
Crystal-induced endogenous pyrogen production. A further look at gouty inflammat...
Crystal-induced endogenous pyrogen production. A further look at gouty inflammation.
Arthritis Rheum. 1985 Sep ;28(9):1039-46.

PubMed
Gait asymmetry in patients with limb-length inequality.
Gait asymmetry in patients with limb-length inequality.
J Pediatr Orthop. 1996 Mar-Apr ;16(2):144-50.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Assessment of the potential pathogenicity of type II collagen autoantibodies in patients with rheumatoid arthritis. Evidence of restricted IgG3 subclass expression and activation of complement C5 to C5a.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Libraries

Supplemental Content

Related citations

Cited by 7 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information