Advancement in the Treatment of Osteoporosis and the Effects on Bone Healing

J Clin Med. 2022 Dec 16;11(24):7477. doi: 10.3390/jcm11247477.

Abstract

Osteoporosis (OP) is a major global health concern, with aging being one of the most important risk factors. Osteoarthritis (OA) is also an age-related disorder. Patients with OP and/or OA may be treated surgically for fractures or when their quality of life is impaired. Poor bone quality due to OP can seriously complicate the stability of a bone fixation construct and/or surgical fracture treatment. This review summarizes the current knowledge on the pathophysiology of normal and osteoporotic bone healing, the effect of a bone fracture on bone turnover markers, the diagnosis of a low bone mineral density (BMD) before surgical intervention, and the effect of available anti-osteoporosis treatment. Interventions that improve bone health may enhance the probability of favorable surgical outcomes. Fracture healing and the treatment of atypical femoral fractures are also discussed.

Keywords: bone-related surgeries; osteoporosis.

Publication types

  • Review

Grants and funding

This work was supported by the Intramural Research Program of the Diabetes and Endocrinology Center of University of South Florida.