Thromb Haemost. 1986 Aug 20;56(1):53-6.

Prophylaxis of thromboembolic disease and platelet-related changes following total hip replacement: a comparative study of aspirin and heparin-dihydroergotamine.

Abstract

A prospective study involving 120 consecutive patients undergoing total hip replacement was performed to compare the effectiveness of aspirin (high and low dose) or a combination of heparin plus dihydroergotamine (heparin-DHE) in preventing isotopic and phlebographic deep vein thrombosis (DVT), and to evaluate their effect on postoperative platelet changes. Phlebographic DVT was demonstrated in 9 cases (30%) in control group, in 1 (3.3%) in aspirin (high-dose) group (p less than 0.01), in 1 (3.3%) in aspirin (low-dose) group (p less than 0.01) and in 5 (16.6%) in heparin-DHE group (p = NS). Aspirin was able to reduce the postoperative increase in circulating platelet aggregates, platelet factor 4 and beta-thromboglobulin observed in control group. This study shows that aspirin is effective in the prevention of DVT for patients undergoing total hip replacement. Small aspirin dose (250 mg/day) represents an effective form of prophylaxis in these patients.

PMID:: 3535158; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Related citations

A fixed-dose combination of low molecular weight heparin with dihydroergotamine versus adjusted-dose unfractionated heparin in the prevention of deep-vein thrombosis after total hip replacement. [Thromb Haemost. 1996]
A fixed-dose combination of low molecular weight heparin with dihydroergotamine versus adjusted-dose unfractionated heparin in the prevention of deep-vein thrombosis after total hip replacement.
Horbach T, Wolf H, Michaelis HC, Wagner W, Hoffmann A, Schmidt A, Beck H. Thromb Haemost. 1996 Feb; 75(2):246-50.
[Thromboembolic disease and changes in coagulation after total hip arthroplasty. Effect of prophylaxis with acetylsalicylic acid or heparin-dihydroergotamine]. [Sangre (Barc). 1986]
[Thromboembolic disease and changes in coagulation after total hip arthroplasty. Effect of prophylaxis with acetylsalicylic acid or heparin-dihydroergotamine].
Alfaro M, Páramo JA, de Pablos J, Cañadell J, Rocha E. Sangre (Barc). 1986; 31(2):145-55.
Prevention of thromboembolism in total hip replacement. Aspirin versus dihydroergotamine-heparin. [Acta Orthop Scand. 1987]
Prevention of thromboembolism in total hip replacement. Aspirin versus dihydroergotamine-heparin.
Josefsson G, Dahlqvist A, Bodfors B. Acta Orthop Scand. 1987 Dec; 58(6):626-9.
Review [Prevention of thromboembolism in surgery]. [Orthopade. 1988]
Review [Prevention of thromboembolism in surgery].
Reilmann H, Bosch U, Barthels M. Orthopade. 1988 Feb; 17(1):110-7.
Review Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. [Ann Surg. 1988]
Review Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis.
Clagett GP, Reisch JS. Ann Surg. 1988 Aug; 208(2):227-40.

See reviews... See all...

Cited by 2 PubMed Central articles

Medical risks during flight deportation of refugees. [Int J Equity Health. 2003]
Medical risks during flight deportation of refugees.
Mirzaei S, Lipp RW, Rodrigues M, Knoll P. Int J Equity Health. 2003 Oct 30; 2(1):9. Epub 2003 Oct 30.
Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration. [BMJ. 1994]
Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration.
. BMJ. 1994 Jan 22; 308(6923):235-46.

Chemical compound information

Dihydroergotamine

MW: 583.67 g/mol

MF: C₃₃H₃₇N₅O₅

See 1 citation for this compound....

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Prophylaxis of thromboembolic disease and platelet-related changes following tot...
Prophylaxis of thromboembolic disease and platelet-related changes following total hip replacement: a comparative study of aspirin and heparin-dihydroergotamine.
Thromb Haemost. 1986 Aug 20 ;56(1):53-6.

PubMed
Cross sectional analysis of mortality by country of birth in England and Wales, ...
Cross sectional analysis of mortality by country of birth in England and Wales, 1970-92.
BMJ. 1997 Mar 8 ;314(7082):705-10.

PubMed
Maternal education and child survival: a comparative study of survey data from 1...
Maternal education and child survival: a comparative study of survey data from 17 countries.
Soc Sci Med. 1993 May ;36(9):1207-27.

PubMed
Preventing heart attack and death in patients with coronary disease.
Preventing heart attack and death in patients with coronary disease.
Circulation. 1995 Jul 1 ;92(1):2-4.

PubMed
Is educational attainment associated with shared determinants of health in the e...
Is educational attainment associated with shared determinants of health in the elderly? Findings from the MacArthur Studies of Successful Aging.
Psychosom Med. 1998 Sep-Oct ;60(5):578-85.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Prophylaxis of thromboembolic disease and platelet-related changes following total hip replacement: a comparative study of aspirin and heparin-dihydroergotamine.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Libraries

Supplemental Content

Related citations

Cited by 2 PubMed Central articles

Chemical compound information

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information