Enterotoxigenic Escherichia coli Heat-Stable Toxin and Ebola Virus Delta Peptide: Similarities and Differences

Lilia I Melnik; Robert F Garry

doi:10.3390/pathogens11020170

Enterotoxigenic Escherichia coli Heat-Stable Toxin and Ebola Virus Delta Peptide: Similarities and Differences

Pathogens. 2022 Jan 27;11(2):170. doi: 10.3390/pathogens11020170.

Authors

Lilia I Melnik^{1

2}, Robert F Garry^{1

2}

Affiliations

¹ Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
² Viral Hemorrhagic Fever Consortium, New Orleans, LA 70112, USA.

Abstract

Enterotoxigenic Escherichia coli (ETEC) STb toxin exhibits striking structural similarity to Ebola virus (EBOV) delta peptide. Both ETEC and EBOV delta peptide are enterotoxins. Comparison of the structural and functional similarities and differences of these two toxins illuminates features that are important in induction of pathogenesis by a bacterial and viral pathogen.

Keywords: Ebola virus; STb; delta peptide; diarrhea; enterotoxigenic Escherichia coli; enterotoxin; mechanisms of fluid secretion.

Publication types

Review

Abstract

Publication types

Grants and funding