Arthritis Rheum. 1988 Apr;31(4):561-5.

Spontaneous cartilage degeneration in guinea pigs.

Source

Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana 46140.

Abstract

Spontaneous degeneration of the knee joint cartilage in male Hartley guinea pigs was studied by light microscopy in animals aged 3-18 months. Unilateral focal degeneration, characterized by chondrocyte death and proteoglycan loss with surface fibrillation, was observed on the medial tibial plateau in 2 of 5 guinea pigs that were 3 months old. The incidence and severity of the lesions increased with age, and by 12-18 months of age, all animals had moderate-to-severe degeneration of the medial tibial plateau, femoral condyle, and meniscus. Lesions were not present on the lateral aspect of the knee joint in any of the animals.

PMID:: 3358814; [PubMed - indexed for MEDLINE]

MeSH Terms

LinkOut - more resources

Medical

Seniors' Health - MedlinePlus Health Information

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Osteoarthrosis in guinea pigs: histopathologic and scanning electron microscopic features. [Lab Anim Sci. 1989]
Osteoarthrosis in guinea pigs: histopathologic and scanning electron microscopic features.
Bendele AM, White SL, Hulman JF. Lab Anim Sci. 1989 Mar; 39(2):115-21.
Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes. [Lab Anim Sci. 1997]
Spontaneous osteoarthritis in Dunkin Hartley guinea pigs: histologic, radiologic, and biochemical changes.
Jimenez PA, Glasson SS, Trubetskoy OV, Haimes HB. Lab Anim Sci. 1997 Dec; 47(6):598-601.
Early alterations in the collagen meshwork and lesions in the ankles are associated with spontaneous osteoarthritis in guinea-pigs. [Osteoarthritis Cartilage. 2002]
Early alterations in the collagen meshwork and lesions in the ankles are associated with spontaneous osteoarthritis in guinea-pigs.
Han B, Cole AA, Shen Y, Brodie T, Williams JM. Osteoarthritis Cartilage. 2002 Oct; 10(10):778-84.
Review Articular cartilage lesions in the symptomatic anterior cruciate ligament-deficient knee. [Arthroscopy. 2003]
Review Articular cartilage lesions in the symptomatic anterior cruciate ligament-deficient knee.
Maffulli N, Binfield PM, King JB. Arthroscopy. 2003 Sep; 19(7):685-90.
Review Arthroscopic evaluation of articular cartilage lesions in posterior-cruciate-ligament-deficient knees. [Arthroscopy. 2003]
Review Arthroscopic evaluation of articular cartilage lesions in posterior-cruciate-ligament-deficient knees.
Strobel MJ, Weiler A, Schulz MS, Russe K, Eichhorn HJ. Arthroscopy. 2003 Mar; 19(3):262-8.

See reviews... See all...

Cited by 19 PubMed Central articles

Expression of vascular endothelial growth factor (VEGF) associated with histopathological changes in rodent models of osteoarthritis. [J Toxicol Pathol. 2011]
Expression of vascular endothelial growth factor (VEGF) associated with histopathological changes in rodent models of osteoarthritis.
Yamairi F, Utsumi H, Ono Y, Komorita N, Tanaka M, Fukunari A. J Toxicol Pathol. 2011 Jun; 24(2):137-42. Epub 2011 Jun 30.
Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease. [Osteoarthritis Cartilage. 2011]
Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease.
Knott L, Avery NC, Hollander AP, Tarlton JF. Osteoarthritis Cartilage. 2011 Sep; 19(9):1150-7. Epub 2011 Jul 1.
The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig. [Osteoarthritis Cartilage. 2010]
The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig.
Kraus VB, Huebner JL, DeGroot J, Bendele A. Osteoarthritis Cartilage. 2010 Oct; 18 Suppl 3:S35-52.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Spontaneous cartilage degeneration in guinea pigs.
Spontaneous cartilage degeneration in guinea pigs.
Arthritis Rheum. 1988 Apr ;31(4):561-5.

PubMed
The affinity and spectrum of cross reactivity of antibody production in senescen...
The affinity and spectrum of cross reactivity of antibody production in senescent mice: the IgM response.
Mech Ageing Dev. 1977 Sep-Oct ;6(5):385-92.

PubMed
Impaired glucose handling in active rheumatoid arthritis: effects of corticoster...
Impaired glucose handling in active rheumatoid arthritis: effects of corticosteroids and antirheumatic treatment.
Metabolism. 1987 Oct ;36(10):944-8.

PubMed
Complement activation by the alternative pathway and macrophage enzyme secretion...
Complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation.
Immunology. 1977 Jun ;32(6):929-40.

PubMed
Acute inflammation and microthrombosis induced by endotoxin, interleukin-1, and ...
Acute inflammation and microthrombosis induced by endotoxin, interleukin-1, and tumor necrosis factor and their implication in gram-negative infection.
Lab Invest. 1988 Apr ;58(4):365-78.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Spontaneous cartilage degeneration in guinea pigs.

Source

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Medical

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 19 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information