Effect of Selected Factors on the Serum 25(OH)D Concentration in Women Treated for Breast Cancer

Nutrients. 2021 Feb 9;13(2):564. doi: 10.3390/nu13020564.

Abstract

Maintaining an optimal vitamin D concentration reduces the risk of recurrence and extends survival time in patients after breast cancer treatment. Data on vitamin D deficiency among Polish women after breast cancer therapy are limited. Thus, the aim of the study was the analysis of vitamin D status in post-mastectomy patients, considering such factors as seasons, social habits, vitamin D supplementation and its measurements. The study involved 94 women after breast cancer treatment. Serum vitamin D concentration was measured, and a questionnaire, gathering demographic and clinical data regarding cancer, diet, exposure to sun radiation, and knowledge of recommendations on vitamin D supplementation, was delivered twice, in both winter and in summer. The control group consisted of 94 age-matched women with no oncological history. In women after breast cancer treatment, 25-hydroxyvitamin D (25(OH)D) deficiency was much more frequent than in the general population. Only about half of the patients supplemented vitamin D at the beginning of the study. After the first test and the issuing of recommendations on vitamin D supplementation, the percentage of vitamin D supplemented patients increased by about 30% in study groups. The average dose of supplement also increased. None of the women that were not supplementing vitamin D and were tested again in winter had optimal 25(OH)D concentration. It was concluded that vitamin deficiency is common in women treated for breast cancer. Medical advising about vitamin D supplementation and monitoring of 25(OH)D concentration should be improved.

Keywords: breast cancer; vitamin D deficiency; vitamin D measurement; vitamin D supplementation.

MeSH terms

  • Adult
  • Breast Neoplasms / blood*
  • Breast Neoplasms / surgery*
  • Diet
  • Dietary Supplements
  • Female
  • Humans
  • Mastectomy
  • Middle Aged
  • Poland / epidemiology
  • Seasons
  • Sunlight
  • Surveys and Questionnaires
  • Vitamin D / administration & dosage
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / epidemiology*

Substances

  • Vitamin D
  • 25-hydroxyvitamin D