Mol Endocrinol. 1987 Jun;1(6):430-4.

Regulation of 70-kilodalton heat-shock-like messenger ribonucleic acid in vitro and in vivo by prolactin.

deToledo SM, Murphy LJ, Hatton TH, Friesen HG.

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Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.

Abstract

A cDNA clone, pNb29, was isolated from a library made from mRNA of Nb2 rat lymphoma cells stimulated by PRL. The nucleotide sequence of pNb29 was found to be identical to the 70-kilodalton heat-shock-like (hsp-70-like) mRNA. The levels of this mRNA increased 8 +/- 3-fold after PRL stimulation of arrested Nb2 cells, and is expressed in different amounts in the normal rat tissues analyzed. To determine whether hsp-70-like mRNA was PRL responsive in vivo, ovine PRL was administered to hypophysectomized rats. A 5 +/- 2-fold increase in hepatic hsp-70-like mRNA was observed 9 h after injection. Thus PRL appears to regulate a heat-shock-like mRNA both in vitro and in vivo. This novel finding extends the already wide range of biological effects ascribed to PRL.

PMID:: 3274897; [PubMed - indexed for MEDLINE]

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Cited by 3 PubMed Central articles

Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques. [Genome Biol. 2000]
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