Clin Orthop Relat Res. 1988 Nov;(236):233-9.

Cartilaginous transdifferentiation of rat tenosynovial cells under the influence of bone morphogenetic protein in tissue culture.

Source

Department of Orthopaedics, Nagoya University School of Medicine, Japan.

Abstract

In an in vitro system cartilage tissue was formed from the patellar ligament of young adult rats in the crevices of bone matrix gelatin (BMG) under the influence of bone morphogenetic protein (BMP). The rate of cartilage induction was 75% (six of eight) for the explants using patellar ligaments of rat knee joints. Almost the same rate was observed, 67% (four of six), for explants of ligament with fatty tissue. Tenosynovial cells and synovial cells from the surface of ligaments are potent responders to BMP, and this property may be applied to accelerate the biologic attachment of excised tendons and ligaments in clinical practice.

PMID:: 3180577; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue. [Arthritis Rheum. 2007]
Chondrogenic differentiation of bovine synovium: bone morphogenetic proteins 2 and 7 and transforming growth factor beta1 induce the formation of different types of cartilaginous tissue.
Shintani N, Hunziker EB. Arthritis Rheum. 2007 Jun; 56(6):1869-79.
Differentiation of cartilage on three substrata under the influence of an aggregate of morphogenetic protein and other bone tissue noncollagenous proteins (BMP/iNCP). [Clin Orthop Relat Res. 1986]
Differentiation of cartilage on three substrata under the influence of an aggregate of morphogenetic protein and other bone tissue noncollagenous proteins (BMP/iNCP).
Takahashi S, Urist MR. Clin Orthop Relat Res. 1986 Jun; (207):227-38.
Bone morphogenetic protein-induced muscle- and synovium-derived cartilage differentiation in vitro. [Clin Orthop Relat Res. 1993]
Bone morphogenetic protein-induced muscle- and synovium-derived cartilage differentiation in vitro.
Iwata H, Ono S, Sato K, Sato T, Kawamura M. Clin Orthop Relat Res. 1993 Nov; (296):295-300.
Review Bone matrix-directed chondrogenesis of muscle in vitro. [Clin Orthop Relat Res. 1985]
Review Bone matrix-directed chondrogenesis of muscle in vitro.
Nathanson MA. Clin Orthop Relat Res. 1985 Nov; (200):142-58.
Review Symbiosis of biotechnology and biomaterials: applications in tissue engineering of bone and cartilage. [J Cell Biochem. 1994]
Review Symbiosis of biotechnology and biomaterials: applications in tissue engineering of bone and cartilage.
Reddi AH. J Cell Biochem. 1994 Oct; 56(2):192-5.

See reviews... See all...

Cited by 3 PubMed Central articles

Expression of bone morphogenetic protein-2 in the chondrogenic and ossifying sites of calcific tendinopathy and traumatic tendon injury rat models. [J Orthop Surg Res. 2009]
Expression of bone morphogenetic protein-2 in the chondrogenic and ossifying sites of calcific tendinopathy and traumatic tendon injury rat models.
Lui PP, Chan LS, Cheuk YC, Lee YW, Chan KM. J Orthop Surg Res. 2009 Jul 21; 4:27. Epub 2009 Jul 21.
Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff. [Arthritis Res Ther. 2006]
Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff.
Neuwirth J, Fuhrmann RA, Veit A, Aurich M, Stonâns I, Trommer T, Hortschansky P, Chubinskaya S, Mollenhauer JA. Arthritis Res Ther. 2006; 8(4):R92.
Review Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical load. [J Anat. 2006]
Review Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical load.
Benjamin M, Toumi H, Ralphs JR, Bydder G, Best TM, Milz S. J Anat. 2006 Apr; 208(4):471-90.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cartilaginous transdifferentiation of rat tenosynovial cells under the influence...
Cartilaginous transdifferentiation of rat tenosynovial cells under the influence of bone morphogenetic protein in tissue culture.
Clin Orthop Relat Res. 1988 Nov ;(236):233-9.

PubMed
Antibodies to small nuclear RNAs complexed with proteins are produced by patient...
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus.
Proc Natl Acad Sci U S A. 1979 Nov ;76(11):5495-9.

PubMed
Transforming growth factor beta stimulates collagen and glycosaminoglycan biosyn...
Transforming growth factor beta stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes.
FEBS Lett. 1988 Jul 4 ;234(1):172-6.

PubMed
Localization of the immune response in sarcoidosis.
Localization of the immune response in sarcoidosis.
Am Rev Respir Dis. 1979 Jul ;120(1):49-57.

PubMed
Elevated von Willebrand factor antigen in systemic sclerosis: relationship to vi...
Elevated von Willebrand factor antigen in systemic sclerosis: relationship to visceral disease.
Br J Rheumatol. 1988 Aug ;27(4):281-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: