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    Cell. 1988 Jul 29;54(3):291-8.

    A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster.

    Source

    Institute of Zoology, University of Zürich, Switzerland.

    Abstract

    The adult male accessory glands of D. melanogaster synthesize and secrete a peptide that represses female sexual receptivity and stimulates oviposition. Normally, this peptide is transferred to females during copulation; however, the peptide shows the same biological activity after purification and subsequent injection into the abdominal cavity of female virgins. Amino acid sequencing of the purified peptide and oligonucleotide-directed cDNA cloning established that the peptide consists of 36 amino acids. It appears to be synthesized as a precursor with a hydrophobic signal sequence of 19 residues at its N-terminal end. The precursor peptide is encoded by a short mRNA that accumulates exclusively in the male accessory gland. The gene has been localized by in situ hybridization to polytene chromosomes at 70A.

    PMID:
    3135120
    [PubMed - indexed for MEDLINE]

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