The Interplay Between Age and Frailty in People Living With HIV: Results From an 11-Year Follow-up Observational Study

Giovanni Guaraldi; Davide De Francesco; Jovana Milic; Iacopo Franconi; Cristina Mussini; Julian Falutz; Matteo Cesari

doi:10.1093/ofid/ofz199

The Interplay Between Age and Frailty in People Living With HIV: Results From an 11-Year Follow-up Observational Study

Open Forum Infect Dis. 2019 May 17;6(5):ofz199. doi: 10.1093/ofid/ofz199. eCollection 2019 May.

Authors

Giovanni Guaraldi¹, Davide De Francesco², Jovana Milic^{1

3}, Iacopo Franconi¹, Cristina Mussini¹, Julian Falutz⁴, Matteo Cesari^{5

6}

Affiliations

¹ Modena HIV Metabolic Clinic, Infectious Diseases Unit, University of Modena and Reggio Emilia, Italy.
² Institute for Global Health, University College London, London, UK.
³ Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
⁴ McGill University Hospital Centre, Montreal, Quebec, Canada.
⁵ Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
⁶ Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.

Abstract

Between 2006 and 2017, frailty prevalence decreased in HIV-positive individuals aged 50 years but presented a 3-fold increase among those 75 years of age. This dynamic relationship, defined as the frailty compression ratio, represents the net result of gero-inducing and gero-protective competing forces, described in the cohort.

Keywords: HIV; aging; frailty; frailty compression; gero-inducer; gero-protector.