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    Clin Exp Immunol. 1978 Sep;33(3):441-52.

    Studies of surface immunoglobulins on human B lymphocytes. III. Physiological variations of SIg+ cells in peripheral blood.

    Abstract

    The levels of B lymphocytes bearing surface immunoglobulins in human peripheral blood were measured by immunofluorescence after pre-treatment of the cells with a low pH shock or washing at 37 degrees C. It was found that the percentages of SIg-bearing cells in an individual varied throughout the day and showed a circadian rhythm with a peak at 12 midnight and a depression at 12 noon. In addition, the levels of the B lymphocytes in the peripheral blood were shown to vary annually, being lower in the winter than in the summer.

    PMID:
    310741
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1537443
    Free PMC Article

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