Clin Exp Rheumatol. 1986 Oct-Dec;4(4):319-21.

Factor VIII complex in progressive systemic sclerosis.

Pagano L, Marra R, Paoletti S, Afa G, Storti S, Garcovich A, Bizzi B.

Abstract

Factor VIII complex and its related activities (Coagulant, Antigen and Ristocetin Cofactor) have been investigated in 23 patients with Progressive Systemic Sclerosis (PSS) divided into two groups: acrosclerosis and diffuse sclerosis. All Factor VIII-related activities were higher in PSS patients than in normal subjects. No difference in F. VIII-related Antigen (F. VIIIR:Ag), F. VIII-related Ristocetin Cofactor (F. VIIIR:Co) and F. VIII Coagulant activity (F. VIII:C) was found comparing the patient groups. F. VIII:C was increased significantly less than F. VIIIR:Ag and F. VIIIR:Co in both patient groups. Some hypotheses about the pathogenesis of this increase are discussed.

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An evaluation of some inflammatory, coagulative and immune factors in progressive systemic sclerosis. [Panminerva Med. 1989]
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Cited by 1 PubMed Central article

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Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma).
Scheja A, Akesson A, Geborek P, Wildt M, Wollheim CB, Wollheim FA, Vischer UM. Arthritis Res. 2001; 3(3):178-82. Epub 2001 Feb 19.

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