Pain. 1978 Jun;5(1):65-71.

Plasma tryptophan and musculoskeletal pain in non-articular rheumatism ("fibrositis syndrome").

Abstract

Plasma-free tryptophan is inversely related to the severity of subjective pain in 8 patients who fulfilled criteria for a variety of non-articular rheumatism, the "fibrositis syndrome". The observation is consistent with animal and human studies suggesting a relationship between reduced brain serotonin metabolism and pain reactivity.

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