Proc Natl Acad Sci U S A. 1985 Sep;82(17):5724-7.

An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli.

Abraham JM, Freitag CS, Clements JR, Eisenstein BI.

Abstract

The expression of type 1 fimbriae (pili) of Escherichia coli is turned on and off at the transcriptional level at a high frequency (10(-3) per cell per generation) in a process termed phase variation. Using Southern blot and DNA sequence analysis, we have detected a genomic rearrangement in the switch region immediately upstream of the fimbrial structural gene. This rearrangement involves an invertible 314-base-pair segment of DNA whose alternating orientation apparently results in the on-and-off activation of a promoter that determines the state of fimbrial expression.

PMID:: 2863818; [PubMed - indexed for MEDLINE]
PMCID:: PMC390624

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Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

DNA, Bacterial

Secondary Source ID

Grant Support

AI19670/AI/NIAID NIH HHS/United States

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