Proc Natl Acad Sci U S A. 1978 Feb;75(2):559-63.

Respective roles of short- and long-range interactions in protein folding.

Abstract

A lattice model of protein is studied by a Monte Carlo simulation method. The native conformation of the lattice protein molecule is stabilized by specific long-range and short-ranged interactions. By comparing results of simulation for different relative weights of the long- and short-range interactions, it is concluded that the specific long-range interactions are essential for highly cooperative stabilization of the native conformation and that the short-range interactions accelerate the folding and unfolding transitions.

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Respective roles of short- and long-range interactions in protein folding.

Abstract

MeSH Terms

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LinkOut - more resources

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Cited by 29 PubMed Central articles

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