Proc Natl Acad Sci U S A. 1977 Aug;74(8):3550-4.

Fatty liver induced in Zucker "fatty" (ff) rats by a semisynthetic diet rich in sucrose.

Abstract

A new fatty liver model is described in which heredity plays a major role. A marked fatty liver develops when the homozygous mutant Zucker rat (ff or "fatty") is fed a semi-synthetic diet enriched in sucrose. Lean littermates do not develop fatty livers on this experimental diet. Even old ff rats do not develop fatty livers on chow; the experimental diet is required. The fatty liver is described, including light microscopic and preliminary electron microscopic observations.

PMID:: 269413; [PubMed - indexed for MEDLINE]
PMCID:: PMC431629

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Fatty liver induced in Zucker "fatty" (ff) rats by a semisynthetic diet rich in sucrose. [Proc Natl Acad Sci U S A. 1977]
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