Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

Soheil Zorofchian Moghadamtousi; Mehran Fadaeinasab; Sonia Nikzad; Gokula Mohan; Hapipah Mohd Ali; Habsah Abdul Kadir

doi:10.3390/ijms160715625

Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

Int J Mol Sci. 2015 Jul 10;16(7):15625-58. doi: 10.3390/ijms160715625.

Authors

Soheil Zorofchian Moghadamtousi¹, Mehran Fadaeinasab², Sonia Nikzad³, Gokula Mohan⁴, Hapipah Mohd Ali⁵, Habsah Abdul Kadir⁶

Affiliations

¹ Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. soheil.zorofchian@gmail.com.
² Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. mehranfadaei@um.edu.my.
³ Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. sonia.nikzad@gmail.com.
⁴ Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. g.mohan@um.edu.my.
⁵ Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. hapipah@um.edu.my.
⁶ Biomolecular Research Group, Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. habsah@um.edu.my.

Abstract

Annona muricata is a member of the Annonaceae family and is a fruit tree with a long history of traditional use. A. muricata, also known as soursop, graviola and guanabana, is an evergreen plant that is mostly distributed in tropical and subtropical regions of the world. The fruits of A. muricata are extensively used to prepare syrups, candies, beverages, ice creams and shakes. A wide array of ethnomedicinal activities is contributed to different parts of A. muricata, and indigenous communities in Africa and South America extensively use this plant in their folk medicine. Numerous investigations have substantiated these activities, including anticancer, anticonvulsant, anti-arthritic, antiparasitic, antimalarial, hepatoprotective and antidiabetic activities. Phytochemical studies reveal that annonaceous acetogenins are the major constituents of A. muricata. More than 100 annonaceous acetogenins have been isolated from leaves, barks, seeds, roots and fruits of A. muricata. In view of the immense studies on A. muricata, this review strives to unite available information regarding its phytochemistry, traditional uses and biological activities.

Keywords: Annona muricata; acetogenins; annonaceae; bioactive compounds; biological activity; fruit tree; natural products.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acetogenins / chemistry*
Acetogenins / isolation & purification
Acetogenins / pharmacology
Annona / chemistry*
Annona / metabolism
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology
Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / toxicity
Antioxidants / chemistry
Antioxidants / isolation & purification
Antioxidants / pharmacology
Apoptosis / drug effects
Central Nervous System / drug effects
Central Nervous System Agents / chemistry
Central Nervous System Agents / isolation & purification
Central Nervous System Agents / pharmacology
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / isolation & purification
Hypoglycemic Agents / pharmacology
Oils, Volatile / chemistry
Oils, Volatile / isolation & purification
Oils, Volatile / pharmacology

Substances

Acetogenins
Anti-Infective Agents
Anti-Inflammatory Agents
Antineoplastic Agents, Phytogenic
Antioxidants
Central Nervous System Agents
Hypoglycemic Agents
Oils, Volatile