Nature. 1989 May 25;339(6222):280-6.

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.

Source

Department of Biochemistry and Biophysics, School of Medicine, University of California, San Francisco 94143-0448.

Abstract

We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.

PMID:: 2566918; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Cyclin synthesis drives the early embryonic cell cycle. [Nature. 1989]
Cyclin synthesis drives the early embryonic cell cycle.
Murray AW, Kirschner MW. Nature. 1989 May 25; 339(6222):275-80.
Cyclin B2/cyclin-dependent kinase1 dissociation precedes CDK1 Thr-161 dephosphorylation upon M-phase promoting factor inactivation in Xenopus laevis cell-free extract. [Int J Dev Biol. 2007]
Cyclin B2/cyclin-dependent kinase1 dissociation precedes CDK1 Thr-161 dephosphorylation upon M-phase promoting factor inactivation in Xenopus laevis cell-free extract.
Chesnel F, Bazile F, Pascal A, Kubiak JZ. Int J Dev Biol. 2007; 51(4):297-305.
Review Maturation promoting factor, cyclin and the control of M-phase. [Curr Opin Cell Biol. 1989]
Review Maturation promoting factor, cyclin and the control of M-phase.
Hunt T. Curr Opin Cell Biol. 1989 Apr; 1(2):268-74.
Cyclin B dissociation from CDK1 precedes its degradation upon MPF inactivation in mitotic extracts of Xenopus laevis embryos. [Cell Cycle. 2006]
Cyclin B dissociation from CDK1 precedes its degradation upon MPF inactivation in mitotic extracts of Xenopus laevis embryos.
Chesnel F, Bazile F, Pascal A, Kubiak JZ. Cell Cycle. 2006 Aug; 5(15):1687-98. Epub 2006 Aug 1.
Review The role of cyclin synthesis, modification and destruction in the control of cell division. [J Cell Sci Suppl. 1989]
Review The role of cyclin synthesis, modification and destruction in the control of cell division.
Minshull J, Pines J, Golsteyn R, Standart N, Mackie S, Colman A, Blow J, Ruderman JV, Wu M, Hunt T. J Cell Sci Suppl. 1989; 12:77-97.

See reviews... See all...

Cited by over 100 PubMed Central articles

Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. [PLoS One. 2011]
Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia.
Zhang Y, van Deursen J, Galardy PJ. PLoS One. 2011; 6(8):e23389. Epub 2011 Aug 11.
Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts. [Enzyme Res. 2011]
Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts.
Kubiak JZ, El Dika M. Enzyme Res. 2011; 2011:523420. Epub 2011 Jun 22.
Microtubule assembly in meiotic extract requires glycogen. [Mol Biol Cell. 2011]
Microtubule assembly in meiotic extract requires glycogen.
Groen AC, Coughlin M, Mitchison TJ. Mol Biol Cell. 2011 Sep; 22(17):3139-51. Epub 2011 Jul 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of cyclin synthesis and degradation in the control of maturation promot...
The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.
Nature. 1989 May 25 ;339(6222):280-6.

PubMed
Recombination between dispersed serine tRNA genes in Schizosaccharomyces pombe.
Recombination between dispersed serine tRNA genes in Schizosaccharomyces pombe.
Nature. 1982 Nov 18 ;300(5889):225-31.

PubMed
Transcriptional regulation of a pair-rule stripe in Drosophila.
Transcriptional regulation of a pair-rule stripe in Drosophila.
Genes Dev. 1991 May ;5(5):827-39.

PubMed
Challenging times for bioinformatics.
Challenging times for bioinformatics.
Nature. 1995 Aug 24 ;376(6542):647-8.

PubMed
Cloning of genomic and complementary DNA from Shaker, a putative potassium chann...
Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.
Science. 1987 Aug 14 ;237(4816):749-53.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Libraries

Supplemental Content

Related citations

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information