Antimicrob Agents Chemother. 1989 Aug;33(8):1395-9.

Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.

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Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115.

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Antimicrob Agents Chemother 1989 Oct;33(10):1827.

Abstract

Two mutants defective in herpes simplex virus-encoded ribonucleotide reductase activity exhibited the novel phenotype of hypersensitivity to acyclovir, aphidicolin, and to a lesser extent, phosphonoacetic acid. These results have implications for acyclovir resistance and the development of drugs that potentiate acyclovir action by inhibition of viral ribonucleotide reductase.

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Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir.

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