Fast method for synthesis of alkyl and aryl-N-methylnitrones

Serkan Yavuz; Hamdi Ozkan; Naki Colak; Yilmaz Yildirir

doi:10.3390/molecules16086677

Fast method for synthesis of alkyl and aryl-N-methylnitrones

Molecules. 2011 Aug 8;16(8):6677-83. doi: 10.3390/molecules16086677.

Authors

Serkan Yavuz¹, Hamdi Ozkan², Naki Colak³, Yilmaz Yildirir⁴

Affiliations

¹ Chemistry Department, Faculty of Science, Gazi University, Ankara 06500, Turkey.
² Chemistry Department, Faculty of Science, Çankırı Karatekin University, Çankırı 18100, Turkey.
³ Chemistry Department, Faculty of Science and Arts, Hitit University, Çorum 19030, Turkey.
⁴ Chemistry Department, Faculty of Science, Gazi University, Ankara 06500, Turkey. yildirir@gazi.edu.tr.

Abstract

A simple, fast, efficient and eco-friendly procedure was developed for the synthesis of alkyl and aryl-N-methylnitrones. The corresponding nitrones of aromatic aldehydes, aliphatic aldehydes and alicyclic carbonyl compounds were prepared from N-methylhydroxylamine hydrochloride and Na2CO3-Na2SO4 by simply grinding at room temperature without using solvent.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemistry, Organic / methods*
Nitrogen Oxides / chemical synthesis*
Nitrogen Oxides / chemistry
Proton Magnetic Resonance Spectroscopy
Time Factors
Transition Temperature

Substances

Nitrogen Oxides
nitrones