Nature. 1978 Feb 16;271(5646):618-21.

Structural evidence for gene duplication in the evolution of the acid proteases.

Tang J, James MN, Hsu IN, Jenkins JA, Blundell TL.

Abstract

X-ray studies of acid proteases indicate a bilobal structure with a well defined active site cleft. An intramolecular twofold symmetry axis relates two topologically similar domains and the active site residues. A possible mechanism for evolution by gene duplication, divergence and gene fusion is presented.

PMID:: 24179; [PubMed - indexed for MEDLINE]

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Peptide Hydrolases

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Structures reported by this article

Structure And Refinement Of Penicillopepsin At 1.8 Angstroms Resolution

PDB: 3APP

Source: Penicillium janthinellum

Method: X-Ray Diffraction

Resolution: 1.8 Å

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Structural evidence for gene duplication in the evolution of the acid proteases.

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