Abstract
Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells in the tumor microenvironment, contributing to tumor immunological escapes. Many studies have demonstrated that multiple factors could induce myeloid precursor cells into myeloid-derived suppressor cells, not dendritic cells. In our study, we found that tumor supernatants could induce the generation of myeloid-derived suppressor cells by disturbing the development of dendritic cells. Twist and miR-34a may regulate the effect of tumor cells inducing myeloid-derived suppressor cells via TGF-β and/or IL-10.
MeSH terms
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Animals
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Cell Differentiation / genetics
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Dendritic Cells / metabolism
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Dendritic Cells / pathology
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Female
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Interleukin-10 / genetics
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Interleukin-10 / metabolism
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Male
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Mice
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Mice, Inbred C57BL
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MicroRNAs / genetics*
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MicroRNAs / metabolism*
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Myeloid Cells / metabolism
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Myeloid Cells / pathology*
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Neoplasms / genetics
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Neoplasms / metabolism
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Neoplasms / pathology*
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Transforming Growth Factor beta / genetics
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Transforming Growth Factor beta / metabolism
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Twist-Related Protein 1 / genetics*
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Twist-Related Protein 1 / metabolism*
Substances
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IL10 protein, mouse
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MIRN34a microRNA, mouse
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MicroRNAs
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Transforming Growth Factor beta
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Twist-Related Protein 1
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Interleukin-10