Science. 1985 Oct 4;230(4721):71-3.

Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III.

Letvin NL, Daniel MD, Sehgal PK, Desrosiers RC, Hunt RD, Waldron LM, MacKey JJ, Schmidt DK, Chalifoux LV, King NW.

Abstract

The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.

PMID:: 2412295; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Related citations

Humoral immune responses to T cell tropic retrovirus simian T lymphotropic virus type III in monkeys with experimentally induced acquired immune deficiency-like syndrome. [J Clin Invest. 1986]
Humoral immune responses to T cell tropic retrovirus simian T lymphotropic virus type III in monkeys with experimentally induced acquired immune deficiency-like syndrome.
Kannagi M, Kiyotaki M, Desrosiers RC, Reimann KA, King NW, Waldron LM, Letvin NL. J Clin Invest. 1986 Nov; 78(5):1229-36.
Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. [Science. 1985]
Isolation of T-cell tropic HTLV-III-like retrovirus from macaques.
Daniel MD, Letvin NL, King NW, Kannagi M, Sehgal PK, Hunt RD, Kanki PJ, Essex M, Desrosiers RC. Science. 1985 Jun 7; 228(4704):1201-4.
Simian models for AIDS. [Cancer Detect Prev Suppl. 1987]
Simian models for AIDS.
Daniel MD, Desrosiers RC, Letvin NL, King NW, Schmidt DK, Sehgal P, Hunt RD. Cancer Detect Prev Suppl. 1987; 1:501-7.
Review Retroviruses associated with leukemia and ablative syndromes in animals and in human beings. [Cancer Res. 1985]
Review Retroviruses associated with leukemia and ablative syndromes in animals and in human beings.
Essex M, McLane MF, Kanki P, Allan J, Kitchen L, Lee TH. Cancer Res. 1985 Sep; 45(9 Suppl):4534s-4538s.
Review The origins of HIV-1 and HTLV-4/HIV-2. [Ann N Y Acad Sci. 1987]
Review The origins of HIV-1 and HTLV-4/HIV-2.
Kanki PJ, Hopper JR, Essex M. Ann N Y Acad Sci. 1987; 511:370-5.

See reviews... See all...

Cited by over 100 PubMed Central articles

Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography. [J Virol. 2011]
Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.
White TA, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Nandwani R, Hoxie JA, Bess JW, Lifson JD, Milne JL, Subramaniam S. J Virol. 2011 Dec; 85(23):12114-23. Epub 2011 Sep 21.
KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif. [PLoS Pathog. 2011]
KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.
Colantonio AD, Bimber BN, Neidermyer WJ Jr, Reeves RK, Alter G, Altfeld M, Johnson RP, Carrington M, O'Connor DH, Evans DT. PLoS Pathog. 2011 Mar; 7(3):e1001316. Epub 2011 Mar 10.
Review Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies. [J Transl Med. 2011]
Review Conformational HIV-1 envelope on particulate structures: a tool for chemokine coreceptor binding studies.
Tagliamonte M, Tornesello ML, Buonaguro FM, Buonaguro L. J Transl Med. 2011 Jan 27; 9 Suppl 1:S1. Epub 2011 Jan 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus ...
Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III.
Science. 1985 Oct 4 ;230(4721):71-3.

PubMed
Humoral immune response of asymptomatic cats naturally infected with feline leuk...
Humoral immune response of asymptomatic cats naturally infected with feline leukemia virus.
J Virol. 1986 Nov ;60(2):669-73.

PubMed
Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy hom...
Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.
N Engl J Med. 1981 Dec 10 ;305(24):1425-31.

PubMed
In vitro activity of inhibitors of late stages of the replication of HIV in chro...
In vitro activity of inhibitors of late stages of the replication of HIV in chronically infected macrophages.
J Leukoc Biol. 1994 Sep ;56(3):381-6.

PubMed
Severe acquired immunodeficiency in male homosexuals, manifested by chronic peri...
Severe acquired immunodeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions.
N Engl J Med. 1981 Dec 10 ;305(24):1439-44.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III.

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Libraries

Supplemental Content

Related citations

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information