Abstract
New four eunicellin-based diterpenoids, krempfielins J-M (1-4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1-6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anthozoa / chemistry*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Cytochalasin B / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Dose-Response Relationship, Drug
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Humans
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Inflammation / drug therapy
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N-Formylmethionine Leucyl-Phenylalanine / pharmacology
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Neutrophils / drug effects*
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Neutrophils / metabolism
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Pancreatic Elastase / metabolism
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Spectrum Analysis
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Superoxides / metabolism
Substances
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Anti-Inflammatory Agents
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Diterpenes
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Superoxides
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Cytochalasin B
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N-Formylmethionine Leucyl-Phenylalanine
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Pancreatic Elastase