Gynecol Oncol. 1990 Jan;36(1):152-4.

5-Fluorouracil neurotoxicity.

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Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599.

Abstract

Two cases of 5-fluorouracil-induced neurotoxicity from the University of North Carolina are presented. 5-Fluorouracil metabolism is briefly discussed with reference to possible mechanisms for the neurotoxicity. A possible role for thiamine supplementation in the prevention of this unusual complication is supported by our experience.

PMID:: 2295446; [PubMed - indexed for MEDLINE]

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