Proc Natl Acad Sci U S A. 1990 Nov;87(21):8272-6.

A putative protein kinase gene (kin1+) is important for growth polarity in Schizosaccharomyces pombe.

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Department of Microbiology and Immunology, University of California, San Francisco 94143.

Abstract

Mixed synthetic oligonucleotides encoding a sequence conserved among tyrosine-specific protein kinases were used to probe the genome of the fission yeast Schizosaccharomyces pombe. A single gene (kin1+) was isolated that encodes a putative protein kinase closely related to the KIN1- and KIN2-encoded serine/threonine-specific protein kinases of Saccharomyces cerevisiae. kin1+ is transcribed into a 3.5-kilobase mRNA that contains an uninterrupted open reading frame encoding a polypeptide of 98 kDa. In contrast to results obtained with kin mutants of S. cerevisiae, disruption of the Sc. pombe kin1+ gene resulted in recessive morphological and growth defects. kin1-disrupted cells grew slowly on enriched medium and grew as spheres, in contrast to wild-type Sc. pombe cells, which grow as rods. Relative to kin1+ cells, kin1-disrupted cells were differentially sensitive to lysis by treatment with alpha- and beta-glucanases, suggesting an alteration in either the composition or the organization of their cell walls.

PMID:: 2236039; [PubMed - indexed for MEDLINE]
PMCID:: PMC54937

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Two yeast genes that encode unusual protein kinases. [Proc Natl Acad Sci U S A. 1987]
Two yeast genes that encode unusual protein kinases.
Levin DE, Hammond CI, Ralston RO, Bishop JM. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6035-9.
hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. [EMBO J. 1995]
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Cited by 24 PubMed Central articles

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Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain.
Murphy JM, Korzhnev DM, Ceccarelli DF, Briant DJ, Zarrine-Afsar A, Sicheri F, Kay LE, Pawson T. Proc Natl Acad Sci U S A. 2007 Sep 4; 104(36):14336-41. Epub 2007 Aug 28.

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