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    Exp Transl Stroke Med. 2012 Feb 2;4(1):1.

    An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice.

    Source

    University of Würzburg, Department of Neurology, Würzburg, Germany. Albert_C2@klinik.uni-wuerzburg.de.

    Abstract

    ABSTRACT: Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.

    PMID:
    22300472
    [PubMed - as supplied by publisher]
    PMCID:
    PMC3305492
    Free PMC Article

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