Neuron. 2011 Oct 20;72(2):231-43.

How inhibition shapes cortical activity.

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Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA 92093-0634, USA. jisaacson@ucsd.edu

Abstract

Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition. Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping spontaneous and sensory-evoked cortical activity and thus underscores how a better knowledge of inhibitory circuits is necessary for our understanding of cortical function. We discuss current views of how inhibition regulates the function of cortical neurons and point to a number of important open questions.

PMID:: 22017986; [PubMed - indexed for MEDLINE]
PMCID:: PMC3236361; [Available on 2012/10/20]

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