J Clin Invest. 1990 Jul;86(1):279-85.

The 210-kD nuclear envelope polypeptide recognized by human autoantibodies in primary biliary cirrhosis is the major glycoprotein of the nuclear pore.

Courvalin JC, Lassoued K, Bartnik E, Blobel G, Wozniak RW.

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Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif sur Yvette, France.

Abstract

We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.

PMID:: 2195063; [PubMed - indexed for MEDLINE]
PMCID:: PMC296718

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Autoantibodies from patients with primary biliary cirrhosis recognize a restricted region within the cytoplasmic tail of nuclear pore membrane glycoprotein Gp210. [J Exp Med. 1993]
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