Curr Rheumatol Rev. 2010 May;6(2):108-119.

Interstitial Lung Disease in Idiopathic Inflammatory Myopathy.

Saketkoo LA, Ascherman DP, Cottin V, Christopher-Stine L, Danoff SK, Oddis CV.

Source

Louisiana State University Health Sciences Center, Department of Medicine, Division of Rheumatology, New Orleans, LA, USA.

Abstract

The lung is one of the most common extra-muscular targets in idiopathic inflammatory myopathies (IIM) and interstitial lung disease (ILD) is a prevalent and often devastating manifestation of IIM. IIM-associated ILD (IIM-ILD) contributes to nearly 80% of the mortality in IIM with a reported prevalence of 65% of newly diagnosed IIM cases. Although ILD frequently accompanies clinical and laboratory findings of myositis, overt signs of muscle disease may be absent in the setting of significant lung disease. Understanding the varied scope of presentation of these diseases is essential to providing optimal patient care. This review will provide an in depth examination of ILD in IIM both from a rheumatologic and pulmonary perspective and will discuss the scope of disease, presenting features, genetic associations, pathogenesis, diagnosis, radiographic and histopathologic findings, along with biomarker assessment and a rationale for therapeutic intervention.

PMID:: 21941374; [PubMed]
PMCID:: PMC3092635

Free PMC Article

Images from this publication.See all images (2) Free text

Grant Support

K23 AR053197-01/NIAMS NIH HHS/United States

LinkOut - more resources

Full Text Sources

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Antiendothelial cell antibodies in inflammatory myopathies: distribution among clinical and serologic groups and association with interstitial lung disease. [J Rheumatol. 2000]
Antiendothelial cell antibodies in inflammatory myopathies: distribution among clinical and serologic groups and association with interstitial lung disease.
D'Cruz D, Keser G, Khamashta MA, Direskeneli H, Targoff IN, Miller F, Hughes GR. J Rheumatol. 2000 Jan; 27(1):161-4.
Idiopathic inflammatory myopathy with diffuse alveolar damage. [Clin Rheumatol. 2002]
Idiopathic inflammatory myopathy with diffuse alveolar damage.
Lee CS, Chen TL, Tzen CY, Lin FJ, Peng MJ, Wu CL, Chen PJ. Clin Rheumatol. 2002 Sep; 21(5):391-6.
Review Clinical presentation of the idiopathic inflammatory myopathies. [Rheum Dis Clin North Am. 2002]
Review Clinical presentation of the idiopathic inflammatory myopathies.
Yazici Y, Kagen LJ. Rheum Dis Clin North Am. 2002 Nov; 28(4):823-32.
Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. [Arthritis Rheum. 2009]
Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease.
Richards TJ, Eggebeen A, Gibson K, Yousem S, Fuhrman C, Gochuico BR, Fertig N, Oddis CV, Kaminski N, Rosas IO, et al. Arthritis Rheum. 2009 Jul; 60(7):2183-92.
Review Interstitial lung disease and idiopathic inflammatory myopathies: progress and pitfalls. [Curr Opin Rheumatol. 2010]
Review Interstitial lung disease and idiopathic inflammatory myopathies: progress and pitfalls.
Labirua A, Lundberg IE. Curr Opin Rheumatol. 2010 Nov; 22(6):633-8.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC

Recent activity

Clear Turn Off Turn On

Interstitial Lung Disease in Idiopathic Inflammatory Myopathy.
Interstitial Lung Disease in Idiopathic Inflammatory Myopathy.
Curr Rheumatol Rev. 2010 May;6(2):108-119.

PubMed
Failure of selenium-ace to improve osteoarthritis.
Failure of selenium-ace to improve osteoarthritis.
Br J Rheumatol. 1990 Jun ;29(3):211-3.

PubMed
The gene expression profile of preclinical autoimmune arthritis and its modulati...
The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge.
Arthritis Res Ther. 2011 ;13(5):R143. Epub 2011 Sep 13 .

PubMed
Outcome of first-trimester exposure to low-dose methotrexate in eight patients w...
Outcome of first-trimester exposure to low-dose methotrexate in eight patients with rheumatic disease.
Am J Med. 1990 Jun ;88(6):589-92.

PubMed
Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV ...
Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV and HIV infection.
Arthritis Res Ther. 2011 Aug 19 ;13(4):233.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Interstitial Lung Disease in Idiopathic Inflammatory Myopathy.

Source

Abstract

Grant Support

Grant Support

LinkOut - more resources

Full Text Sources

Libraries

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information