Trends Biochem Sci. 1990 Apr;15(4):139-42.

Prenyl proteins in eukaryotic cells: a new type of membrane anchor.

Source

Howard Hughes Medical Institute Laboratory, Department of Medicine, University of Washington, Seattle 98195.

Abstract

Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.

PMID:: 2187294; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

COS Scholar Universe

Libraries

LinkOut Holdings

Supplemental Content

Save items

Related citations in PubMed

Review The prenylation of proteins. [Bioessays. 1992]
Review The prenylation of proteins.
Sinensky M, Lutz RJ. Bioessays. 1992 Jan; 14(1):25-31.
Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif. [EMBO J. 1989]
Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif.
Vorburger K, Kitten GT, Nigg EA. EMBO J. 1989 Dec 20; 8(13):4007-13.
Review Posttranslational modification of proteins by isoprenoids in mammalian cells. [FASEB J. 1990]
Review Posttranslational modification of proteins by isoprenoids in mammalian cells.
Maltese WA. FASEB J. 1990 Dec; 4(15):3319-28.
Review Eukaryotic RAS proteins and yeast proteins with which they interact. [Curr Top Microbiol Immunol. 1989]
Review Eukaryotic RAS proteins and yeast proteins with which they interact.
Broek D. Curr Top Microbiol Immunol. 1989; 147:155-69.
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. [Science. 1990]
Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein.
Schafer WR, Trueblood CE, Yang CC, Mayer MP, Rosenberg S, Poulter CD, Kim SH, Rine J. Science. 1990 Sep 7; 249(4973):1133-9.

See reviews... See all...

Cited by 77 PubMed Central articles

Phytol-derived novel isoprenoid immunostimulants. [Front Immunol. 2012]
Phytol-derived novel isoprenoid immunostimulants.
Chowdhury RR, Ghosh SK. Front Immunol. 2012; 3:49. Epub 2012 Mar 22.
RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. [Proc Natl Acad Sci U S A. 2011]
RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.
Christiansen JR, Kolandaivelu S, Bergo MO, Ramamurthy V. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8862-6. Epub 2011 May 9.
Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodium falciparum. [Mol Biochem Parasitol. 2011]
Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodium falciparum.
Ayong L, DaSilva T, Mauser J, Allen CM, Chakrabarti D. Mol Biochem Parasitol. 2011 Feb; 175(2):162-8. Epub 2010 Nov 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Prenyl proteins in eukaryotic cells: a new type of membrane anchor.
Prenyl proteins in eukaryotic cells: a new type of membrane anchor.
Trends Biochem Sci. 1990 Apr ;15(4):139-42.

PubMed
The plausible reason why the length of 5' untranslated region is unrelated to or...
The plausible reason why the length of 5' untranslated region is unrelated to organismal complexity.
BMC Res Notes. 2011 Aug 27 ;4:312.

PubMed
Transforming growth factor-beta. Major role in regulation of extracellular matri...
Transforming growth factor-beta. Major role in regulation of extracellular matrix.
Ann N Y Acad Sci. 1990 ;580:225-32.

PubMed
Differential transcriptomic profiles effected by oil palm phenolics indicate nov...
Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes.
BMC Genomics. 2011 Aug 25 ;12:432.

PubMed
Chitin metabolism: a target for drugs against parasites.
Chitin metabolism: a target for drugs against parasites.
Parasitol Res. 1990 ;76(4):283-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Prenyl proteins in eukaryotic cells: a new type of membrane anchor.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Libraries

Supplemental Content

Save items

Related citations in PubMed

Cited by 77 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information