Source
Division of Nutrition and Preventative Medicine, Department of Medicine, William Beaumont Hospital, 4949 Coolidge Highway, Royal Oak, MI 48073, USA. kzalesin@beaumont.edu
Abstract
Obesity promotes a cascade of secondary pathologies including diabetes, insulin resistance, dyslipidemia, inflammation, thrombosis, hypertension, the metabolic syndrome, and OSA, which collectively heighten the risk for cardiovascular disease. Obesity may also be an independent moderator of cardiac risk apart from these comorbid conditions. Rates of obesity and cardiac disease continue to rise in a parallel and exponential manner. Because obesity is potentially one of the most modifiable mediators of cardiovascular morbidity and mortality, effective treatment and prevention interventions should have a profound and favorable impact on public health.
Copyright © 2011 Elsevier Inc. All rights reserved.