Nucleic Acids Res. 1990 Dec 25;18(24):7389-96.

Transcription regulates oxolinic acid-induced DNA gyrase cleavage at specific sites on the E. coli chromosome.

Source

Laboratoire de Microbiologie, INSA Bat 406, Villeurbanne, France.

Abstract

Prominent DNA gyrase-mediated cleavage sites, induced by oxolinic acid, occur at specific, but infrequent, locations on the Escherichia coli chromosome. These sites, which we call toposites, may represent high affinity DNA gyrase binding sites or may mark chromosomal regions that accumulate superhelical stress. Toposites are usually grouped in 5 to 10 kb clusters that are mostly 50 to 100 kb apart. The total number of clusters on the chromosome is between 50 and 100. The location of sites depends on the local sequence. The extent of DNA gyrase cleavage at toposites can be strongly modulated by transcription occurring at as far as 35 kb away.

PMID:: 2175434; [PubMed - indexed for MEDLINE]
PMCID: PMC332877

Free PMC Article

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Libraries

LinkOut Holdings

Supplemental Content

Related citations

DNA gyrase on the bacterial chromosome. Oxolinic acid-induced DNA cleavage in the dnaA-gyrB region. [J Mol Biol. 1988]
DNA gyrase on the bacterial chromosome. Oxolinic acid-induced DNA cleavage in the dnaA-gyrB region.
Franco RJ, Drlica K. J Mol Biol. 1988 May 5; 201(1):229-33.
The spacing of Escherichia coli DNA gyrase sites cleaved in vivo by treatment with oxolinic acid and sodium dodecyl sulfate. [Biochimie. 1984]
The spacing of Escherichia coli DNA gyrase sites cleaved in vivo by treatment with oxolinic acid and sodium dodecyl sulfate.
Béjar S, Bouché JP. Biochimie. 1984 Nov-Dec; 66(11-12):693-700.
DNA gyrase on the bacterial chromosome: DNA cleavage induced by oxolinic acid. [J Mol Biol. 1979]
DNA gyrase on the bacterial chromosome: DNA cleavage induced by oxolinic acid.
Snyder M, Drlica K. J Mol Biol. 1979 Jun 25; 131(2):287-302.
Review [DNA supercoiling and topoisomerases in Escherichia coli]. [Rev Latinoam Microbiol. 1995]
Review [DNA supercoiling and topoisomerases in Escherichia coli].
Gómez-Eichelmann MC, Camacho-Carranza R. Rev Latinoam Microbiol. 1995 Jul-Sep; 37(3):291-304.
Review DNA gyrase and the supercoiling of DNA. [Science. 1980]
Review DNA gyrase and the supercoiling of DNA.
Cozzarelli NR. Science. 1980 Feb 29; 207(4434):953-60.

See reviews... See all...

Cited by 9 PubMed Central articles

Review DNA supercoiling and its role in DNA decatenation and unknotting. [Nucleic Acids Res. 2010]
Review DNA supercoiling and its role in DNA decatenation and unknotting.
Witz G, Stasiak A. Nucleic Acids Res. 2010 Apr; 38(7):2119-33. Epub 2009 Dec 21.
Rapid assessment of the effect of ciprofloxacin on chromosomal DNA from Escherichia coli using an in situ DNA fragmentation assay. [BMC Microbiol. 2009]
Rapid assessment of the effect of ciprofloxacin on chromosomal DNA from Escherichia coli using an in situ DNA fragmentation assay.
Tamayo M, Santiso R, Gosalvez J, Bou G, Fernández JL. BMC Microbiol. 2009 Apr 13; 9:69. Epub 2009 Apr 13.
Spatial patterns of transcriptional activity in the chromosome of Escherichia coli. [Genome Biol. 2004]
Spatial patterns of transcriptional activity in the chromosome of Escherichia coli.
Jeong KS, Ahn J, Khodursky AB. Genome Biol. 2004; 5(11):R86. Epub 2004 Oct 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Transcription regulates oxolinic acid-induced DNA gyrase cleavage at specific si...
Transcription regulates oxolinic acid-induced DNA gyrase cleavage at specific sites on the E. coli chromosome.
Nucleic Acids Res. 1990 Dec 25 ;18(24):7389-96.

PubMed
The URA5 gene is necessary for histoplasma capsulatum growth during infection of...
The URA5 gene is necessary for histoplasma capsulatum growth during infection of mouse and human cells.
Infect Immun. 1999 Feb ;67(2):624-9.

PubMed
A new method of sequencing DNA.
A new method of sequencing DNA.
Anal Biochem. 1988 Nov 1 ;174(2):423-36.

PubMed
A U-snRNA gene-specific upstream element and a -30 'TATA box' are required for t...
A U-snRNA gene-specific upstream element and a -30 'TATA box' are required for transcription of the U2 snRNA gene of Arabidopsis thaliana.
EMBO J. 1989 Dec 1 ;8(12):3875-82.

PubMed
A novel multigene family may encode odorant receptors: a molecular basis for odo...
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.
Cell. 1991 Apr 5 ;65(1):175-87.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Transcription regulates oxolinic acid-induced DNA gyrase cleavage at specific sites on the E. coli chromosome.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Libraries

Supplemental Content

Related citations

Cited by 9 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information