Science. 1990 Nov 9;250(4982):830-2.

Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1.

Hsu DH, de Waal Malefyt R, Fiorentino DF, Dang MN, Vieira P, de Vries J, Spits H, Mosmann TR, Moore KW.

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Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.

Abstract

Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.

PMID:: 2173142; [PubMed - indexed for MEDLINE]

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Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. [Science. 1990]
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Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR. Science. 1990 Jun 8; 248(4960):1230-4.
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