Rev Infect Dis. 1990 Sep-Oct;12 Suppl 7:S701-10.

Epidemiology of cytomegalovirus infections.

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Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.

Abstract

The determinants of cytomegalovirus (CMV) infection and disease can now be understood from studies of newborns, recipients of organ or bone marrow transplants, subjects infected with human immunodeficiency virus, and recipients of blood transfusions. CMV is transmitted to the neonate transplacentally, by passage through a contaminated birth canal, or by ingestion of infected breast milk; to the adult by heterosexual and homosexual sex with an infected partner; and to the transplant recipient by infected organs. A major unsolved problem in the study of CMV is the nature of viral latency. Knowledge regarding the requirements for activation of latent infection at the molecular, cellular, or host level is incomplete. Both viral and host factors may contribute to the successful transmission of CMV by latently infected cells in transplanted organs and transfused blood.

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Review

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Antibodies, Viral

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Cited by 18 PubMed Central articles

Humoral and cellular CMV responses in healthy donors; identification of a frequent population of CMV-specific, CD4+ T cells in seronegative donors. [PLoS One. 2012]
Humoral and cellular CMV responses in healthy donors; identification of a frequent population of CMV-specific, CD4+ T cells in seronegative donors.
Loeth N, Assing K, Madsen HO, Vindeløv L, Buus S, Stryhn A. PLoS One. 2012; 7(2):e31420. Epub 2012 Feb 7.
Enhanced Induction of T Cell Immunity Using Dendritic Cells Pulsed with HIV Tat and HCMV-pp65 Fusion Protein In Vitro. [Immune Netw. 2011]
Enhanced Induction of T Cell Immunity Using Dendritic Cells Pulsed with HIV Tat and HCMV-pp65 Fusion Protein In Vitro.
Park JS, Park SY, Cho HI, Sohn HJ, Kim TG. Immune Netw. 2011 Jun; 11(3):182-9. Epub 2011 Jun 30.
Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. [Proc Natl Acad Sci U S A. 2011]
Expansion of a unique CD57⁺NKG2Chi natural killer cell subset during acute human cytomegalovirus infection.
Lopez-Vergès S, Milush JM, Schwartz BS, Pando MJ, Jarjoura J, York VA, Houchins JP, Miller S, Kang SM, Norris PJ, et al. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):14725-32. Epub 2011 Aug 8.

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